Gene Expression Profile Reveals Hematopoietic-Related Molecule Changes in Response to Hypoxic Exposure

DNA and Cell Biology
Jun XiaoCuiying Li

Abstract

The Qing-Tibet Plateau is characterized by low oxygen pressure, which is an important biomedical and ecological stressor. However, the variation in gene expression during periods of stay on the plateau has not been well studied. We recruited eight volunteers to stay on the plateau for 3, 7, and 30 days. Human Clariom D arrays were used to measure transcriptome changes in the mRNA expression profiles in these volunteers' blood. Analysis of variance (ANOVA) indicated that 699 genes were significantly differentially expressed in response to entering the plateau during hypoxic exposure. The genes with changes in transcript abundance were involved in the terms phosphoprotein, acetylation, protein binding, and protein transport. Furthermore, numerous genes involved in hematopoietic functions, including erythropoiesis and immunoregulation, were differentially expressed in response to hypoxia. This phenomenon may be one of reasons why the majority of people entering the plateau do not have excessive erythrocyte proliferation and are susceptible to infection.

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Datasets Mentioned

BETA
GSE135109

Methods Mentioned

BETA
chip
PCR
glycosylation

Software Mentioned

Transcriptome Analysis Console
Affymetrix NetAffx Analysis
DAVID Bioinformation Resources
PrimerBank
DAVID

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