Gene expression profiles for the human pancreas and purified islets in type 1 diabetes: new findings at clinical onset and in long-standing diabetes.

Clinical and Experimental Immunology
R PlanasM Vives-Pi

Abstract

Type 1 diabetes (T1D) is caused by the selective destruction of the insulin-producing beta cells of the pancreas by an autoimmune response. Due to ethical and practical difficulties, the features of the destructive process are known from a small number of observations, and transcriptomic data are remarkably missing. Here we report whole genome transcript analysis validated by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and correlated with immunohistological observations for four T1D pancreases (collected 5 days, 9 months, 8 and 10 years after diagnosis) and for purified islets from two of them. Collectively, the expression profile of immune response and inflammatory genes confirmed the current views on the immunopathogenesis of diabetes and showed similarities with other autoimmune diseases; for example, an interferon signature was detected. The data also supported the concept that the autoimmune process is maintained and balanced partially by regeneration and regulatory pathway activation, e.g. non-classical class I human leucocyte antigen and leucocyte immunoglobulin-like receptor, subfamily B1 (LILRB1). Changes in gene expression in islets were confined mainly to endocrine and neural genes, some of...Continue Reading

References

Apr 1, 1988·Diabetes·C RicordiD W Scharp
Mar 13, 2001·Annual Review of Immunology·J F Bach, L Chatenoud
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jun 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kevin MaasThomas M Aune
May 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Laurent PoirotDiane Mathis
Mar 10, 2005·Proceedings of the National Academy of Sciences of the United States of America·C KendziorskiM N Gould
Aug 23, 2005·Digestion·Werner CreutzfeldtPaul Georg Lankisch
Feb 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jacques-Eric GottenbergXavier Mariette
Apr 4, 2006·Trends in Endocrinology and Metabolism : TEM·Pablo A Silveira, Shane T Grey
Apr 21, 2006·Immunological Reviews·Emily C BaechlerTimothy W Behrens
May 2, 2006·Statistical Applications in Genetics and Molecular Biology·Gordon K Smyth
Jun 21, 2006·Nature Immunology·Gordon HyattChristophe Benoist
Jul 11, 2006·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·E S ReisL Isaac
Aug 26, 2006·Science·Heather L CashLora V Hooper
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Francesco DottaPiero Marchetti
Jun 28, 2007·The Journal of Clinical Endocrinology and Metabolism·Ellen C KaizerPerrin C White
Nov 6, 2007·Nature Reviews. Immunology·Matthias von HerrathKevan Herold
Jan 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xujing WangMartin J Hessner
Jul 22, 2008·Journal of Leukocyte Biology·Michael Bots, Jan Paul Medema
Sep 20, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Keiichi KodamaC Garrison Fathman
Jan 9, 2009·Clinical and Experimental Immunology·A WillcoxN G Morgan
Jan 17, 2009·Nature Immunology·Matthias von Herrath, Gerald T Nepom

❮ Previous
Next ❯

Citations

Jun 28, 2012·Nucleic Acids Research·TaeHyun HwangRui Kuang
Jan 1, 2012·The Review of Diabetic Studies : RDS·Yulan Jin, Jin-Xiong She
Apr 5, 2014·Journal of Laboratory Physicians·Jianwei ZhouLin Sun
Sep 8, 2015·Journal of Autoimmunity·Iria Gomez-TourinoMark Peakman
Nov 5, 2011·Current Opinion in Immunology·Bart O Roep, Mark Peakman
Feb 8, 2013·The Journal of Pathology·Ken T Coppieters, Matthias von Herrath
Dec 4, 2012·Diabetic Medicine : a Journal of the British Diabetic Association·M Peakman
Jul 25, 2013·Journal of Cellular Physiology·Veronique SecqJuan L Iovanna
May 21, 2013·Seminars in Immunology·Julia PhielerTriantafyllos Chavakis
Apr 4, 2014·Scandinavian Journal of Clinical and Laboratory Investigation·Milaim PepajPer M Thorsby
Aug 6, 2014·Chimerism·Jody YeKathleen M Gillespie
Feb 18, 2011·Chimerism·Berendine VanzylKathleen M Gillespie
Jun 25, 2014·Trends in Endocrinology and Metabolism : TEM·Brittney N NewbyClayton E Mathews
Jan 22, 2015·Apoptosis : an International Journal on Programmed Cell Death·Marta Vives-PiIrma Pujol-Autonell
Apr 22, 2016·Critical Reviews in Biochemistry and Molecular Biology·Helen K Johnston-CareyKelvin J A Davies
Sep 30, 2016·Clinical Reviews in Allergy & Immunology·Ayelet KaminitzNadir Askenasy
Mar 27, 2018·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Mingming LiuRuijuan Xiu
Aug 5, 2017·Hormone Research in Pædiatrics·Mireia FonolledaMarta Vives-Pi
Jul 10, 2014·Seminars in Immunopathology·Peter In't Veld
Jan 26, 2010·Nature Reviews. Immunology·Bart O Roep, Mark Peakman
Dec 7, 2018·The Journal of Endocrinology·Jose CasasnovasKok Lim Kua
Jun 6, 2017·Endocrinology·Reinaldo S Dos SantosDecio L Eizirik
Jul 26, 2019·Clinical and Experimental Immunology·A M SandorR S Friedman
Dec 11, 2019·Current Diabetes Reports·Rebecca C WyattSarah J Richardson
Nov 28, 2013·Current Opinion in Hematology·Manuela Battaglia
Jul 8, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Liron AbuhatziraAbner L Notkins
Nov 7, 2019·International Journal of Molecular Sciences·Leonid KanevskiyElena Kovalenko
Nov 30, 2019·Frontiers in Immunology·Ahmed M AbdellatifNora E Sarvetnick
Feb 8, 2013·Journal of Clinical Gastroenterology·Marta Vives-PiEstíbaliz Ruiz-Ortiz
Feb 18, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eva Codina-BusquetaMercè Martí
Apr 4, 2019·Molecular Medicine Reports·Liwei QianMeili Ding

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Autoimmune Polyendocrine Syndromes

This feed focuses on a rare genetic condition called Autoimmune Polyendocrine Syndromes, which are characterized by autoantibodies against multiple endocrine organs. This can lead to Type I Diabetes.

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.