Gene expression profiles give insight into the molecular pathology of bone in primary hyperparathyroidism

Bone
Sjur ReppeBo Abrahamsen

Abstract

Global gene expression profiling has been used to study the molecular mechanisms of increased bone remodeling caused by PHPT. This disease is a model for chronic over-stimulation of target organs by PTH due to an inappropriate overproduction of the hormone. Hyperactivity of osteoblasts and osteoclasts lead to increased calcium and phosphate mobilization from the skeleton and hypercalcaemia. The ensemble of genes that alter expression and thus is responsible for the effects of chronic PTH stimulation is today largely unknown. The differentiated gene expression profiles revealed characteristic molecular disease modalities which define the bone remodeling abnormalities occurring in PTH dependent osteodystrophy. We analyzed mRNAs in transiliacal bone biopsies from 7 patients with PHPT using Affymetrix HG-U133A Gene Chips containing more than 22000 different probe sets. Similar analyses of the global transcriptional activity were repeated in a second bone biopsy from the same patient taken one year after surgery and reversal of disease parameters. Real time PCR was carried out on many genes for corroboration of the results. Out of more than 14500 different genes examined, 99 which were related to bone and extra-cellular matrix, show...Continue Reading

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Citations

Jul 5, 2007·International Orthopaedics·F BoroveckiS Vukicevic
Aug 29, 2012·Proceedings of the National Academy of Sciences of the United States of America·Nicolas BonnetSerge L Ferrari
Apr 5, 2007·Paediatric Drugs·Iacopo SardiMaura Massimino
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Jun 2, 2021·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J PepeS Minisola

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