Gene expression profiles in Finnish twins with multiple sclerosis

BMC Medical Genetics
Silja SärkijärviIrina Elovaara

Abstract

Since genetic alterations influencing susceptibility to multiple sclerosis (MS), the most common autoimmune demyelinating disease of the central nervous system (CNS), are as yet poorly understood, the purpose of this study was to identify genes responsible for MS by studying monozygotic (MZ) twin pairs discordant for MS. In order to identify genes involved in MS development, the gene expression profiles in blood mononuclear cells obtained from eight MZ twin pairs discordant for MS were analyzed by cDNA microarray technology detecting the expression of 8 300 genes. The twins were collected from the Finnish Twin Cohort Study and both affected subjects and their healthy siblings underwent neurological evaluation and cerebral and spinal magnetic resonance imaging. Gene expressions were confirmed by relative quantitative reverse transcription PCR. It appeared that 25 genes were at least two-fold up-regulated and 15 genes down-regulated in 25% (2/8) of twins with MS when compared to their healthy siblings. Moreover, 6/25 genes were up-regulated in 40% of MS twins and one gene, interferon alpha-inducible protein (clone IFI-6-16) (G1P3), in 50% of them. The six most constantly expressed genes are (1) G1P3, (2) POU domain, class 3, tran...Continue Reading

References

Jan 1, 1990·Advances in Virus Research·P Staeheli
Dec 25, 1986·The New England Journal of Medicine·G C EbersT Grey
Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
Jan 1, 1994·Neurology·C J MumfordD A Compston
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·M WegnerM G Rosenfeld
Mar 1, 1993·Annals of Neurology·A D SadovnickT J Murray
Jun 1, 1996·Glia·J R Connor, S L Menzies
Jun 25, 1998·Revue Scientifique Et Technique·O HallerG Kochs
May 20, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·L Hibbert, G R Foster
May 10, 2000·Neurology·M LuomalaT Lehtimäki
Feb 15, 2001·Neurology·M LuomalaT Lehtimäki
Mar 10, 2001·Acta Neurologica Scandinavica·M L SumelahtiM Hakama
Apr 20, 2001·Journal of the Neurological Sciences·M LuomalaM Hurme
Jun 27, 2001·Multiple Sclerosis : Clinical and Laboratory Research·H B RasmussenJ Clausen
May 22, 2002·Journal of Neurology·Tuula O JalonenIrina Elovaara
Jan 23, 2003·Twin Research : the Official Journal of the International Society for Twin Studies·Jaakko Kaprio, Markku Koskenvuo
Apr 30, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Haizhen ZhuChen Liu
Nov 18, 2003·Acta Neurologica Scandinavica·M LuomalaI Elovaara
Jan 16, 2004·Genes and Immunity·A BonettiP J Tienari
Oct 1, 1997·Journal of Biomedical Optics·Y ChenM L Bittner

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Citations

Jun 13, 2008·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Anthony T RederEd Croze
Jun 12, 2013·Human Molecular Genetics·Dorothee NicklesSergio E Baranzini
Apr 26, 2008·Epilepsia·Ingo HelbigNicholas K Hayward
Dec 18, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Chihiro KakiuchiTadafumi Kato
Jun 2, 2009·Multiple Sclerosis : Clinical and Laboratory Research·C H Hawkes, A J Macgregor
May 29, 2016·Metabolic Brain Disease·Meric A AltinozSinan Guloksuz
Oct 14, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Venugopalan CheriyathErnest C Borden
Jan 25, 2020·Neuroscience and Biobehavioral Reviews·M C BuscarinuG Ristori
Sep 11, 2021·Frontiers in Immunology·Afshin DerakhshaniVito Racanelli

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Methods Mentioned

BETA
array technology
electrophoresis
PCR

Software Mentioned

LightCycler Relative Quantification Software
ImageQuant
STATA
BD [UNK]
GeneSpring
GeneSpring GX

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