Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice.

Cancer Letters
Rong HuAh-Ng Tony Kong

Abstract

Sulforaphane (SFN) is a potent and promising naturally occurring dietary cancer chemopreventive compound that exerts its cancer protective effects by the induction of genes including cellular defensive genes such as phase II detoxifying and antioxidant enzymes. This gene induction primarily occurs via the transcription factor Nrf2 acting on the antioxidant response element (ARE) located at the 5'-flanking region of these genes. In the present study, transcriptional expression profiles of the livers obtained from the nrf2 wild-type mice and the nrf2 knockout (-/-) mice after treatments with vehicle or SFN at 3 and 12h were generated using the Affymetrix 39K oligonucleotide microarray. The Nrf2-dependent, SFN-inducible genes were identified which include detoxification phase I, II drug metabolizing enzymes and phase III transporters. Unexpected clusters of genes include genes for heat shock proteins (HSP), ubiquitin/26S proteasome subunits, and lipid metabolism genes. Collectively, SFN increases the expression of genes through the Nrf2 signaling pathway that directly detoxify exogenous toxins/carcinogens or endogenous reactive oxygen species, and genes involved in the recognition and repair/removal of damaged proteins, which coul...Continue Reading

Citations

Jun 17, 2008·European Journal of Nutrition·John D HayesIan M Eggleston
Jun 11, 2008·Neuromolecular Medicine·Tae Gen SonMark P Mattson
Nov 9, 2010·Oncogene·A Martín-MontalvoR de Cabo
May 8, 2010·Antioxidants & Redox Signaling·John D HayesAlbena T Dinkova-Kostova
Jan 5, 2011·Antioxidants & Redox Signaling·Regina Brigelius-Flohé, Leopold Flohé
Sep 18, 2012·Carcinogenesis·Andrea L BenedictAlbena T Dinkova-Kostova
Nov 29, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Mohammad Hossein Noyan-AshrafBernhard H J Juurlink
May 15, 2012·Nucleic Acids Research·Brian N ChorleyDouglas A Bell
Aug 29, 2007·Acta Pharmacologica Sinica·Yuesheng Zhang, Li Tang
Aug 29, 2007·Acta Pharmacologica Sinica·Melinda Sue Yates, Thomas Wells Kensler
Jul 16, 2010·Science Signaling·Nobunao WakabayashiThomas W Kensler
Mar 11, 2010·Science Signaling·Gerasimos P Sykiotis, Dirk Bohmann
May 22, 2013·Oxidative Medicine and Cellular Longevity·Reuben Howden
Dec 10, 2013·BMC Genomics·Louise M BrignullAxel Nohturfft
May 28, 2013·Oxidative Medicine and Cellular Longevity·Dionysios V ChartoumpekisIoannis G Habeos
Jan 17, 2013·Cell Stress & Chaperones·Sanne M M HensenNicolette H Lubsen
May 13, 2014·Toxicology·Qiang QuCurtis D Klaassen
Jun 15, 2013·Oxidative Medicine and Cellular Longevity·Michelle R CampbellDouglas A Bell
Oct 24, 2013·Nutrition Reviews·Christine A HoughtonJeff S Coombes
Jan 26, 2011·Expert Opinion on Therapeutic Targets·Constance Lay Lay Saw, Ah-Ng Tony Kong
Nov 26, 2011·Expert Review of Clinical Pharmacology·Guangdong Yang
Aug 13, 2009·Expert Opinion on Drug Metabolism & Toxicology·Arthur Cederbaum
Feb 1, 2008·Journal of Pharmaceutical Sciences·Avantika BarveAh-Ng Kong
Mar 13, 2016·Seminars in Oncology·Li YangThomas W Kensler
Dec 24, 2015·Pharmaceuticals·Dipita Bhakta-Guha, Thomas Efferth

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