Gene expression profiles of CD34+ cells in myelodysplastic syndromes: involvement of interferon-stimulated genes and correlation to FAB subtype and karyotype

Blood
A PellagattiJ Boultwood

Abstract

To gain insight into the poorly understood pathophysiology of the myelodysplastic syndromes (MDSs), we have determined the gene expression profiles of the CD34+ cells of 55 patients with MDS by using a comprehensive array platform. These profiles showed many similarities to reported interferon-gamma-induced gene expression in normal CD34+ cells; indeed the 2 most up-regulated genes, IFIT1 and IFITM1, are interferon-stimulated genes (ISGs). Alterations in the expression of ISGs may play a role in the hematologic features of MDS, such as peripheral blood cytopenias. Up-regulation of IFIT1 is a potential diagnostic marker for MDS. We determined whether distinct gene expression profiles were associated with specific FAB and cytogenetic groups. CD34+ cells from patients with refractory anemia with ringed sideroblasts (RARS) showed a particular gene expression profile characterized by up-regulation of mitochondrial-related genes and, in particular, of those of heme synthesis (eg, ALAS2). CD34+ cells from patients with the del(5q) had a distinct gene expression profile, characterized by down-regulation of genes assigned to 5q, and up-regulation of the histone HIST1 gene cluster at chromosome 6p21 and of genes related to the actin cyto...Continue Reading

Citations

Apr 17, 2008·Annals of Hematology·Detlef Haase
Oct 4, 2011·Current Treatment Options in Oncology·Eric PadronAlan F List
Mar 30, 2011·Leukemia·K Theilgaard-MönchL Bullinger
Oct 8, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sa A WangRobert P Hasserjian
Oct 15, 2011·The New England Journal of Medicine·E PapaemmanuilUNKNOWN Chronic Myeloid Disorders Working Group of the International Cancer Genome Consortium
Dec 21, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Fredy SiegristUlrich Certa
Dec 14, 2011·Hematology·Mario CazzolaRosangela Invernizzi
May 10, 2008·Blood·Stephen D Nimer
Jan 13, 2010·Blood·Jianghong WangZhijian Qian
Sep 5, 2008·PLoS Medicine·Adaikalavan RamasamyDouglas G Altman
Apr 10, 2008·PloS One·Jacqueline BoultwoodJames S Wainscoat
Jun 9, 2009·PloS One·Nikolai N KhodarevRalph R Weichselbaum
Jan 7, 2010·PloS One·Nathan C BolesJeffrey M Rosen
Dec 10, 2009·Haematologica·Andreas ReiterMario Cazzola
Jun 3, 2011·Haematologica·Mario Cazzola, Rosangela Invernizzi
Feb 11, 2014·Best Practice & Research. Clinical Haematology·Luca Malcovati, Mario Cazzola
Jan 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·Arnold GanserEva M Weissinger
Dec 18, 2013·Oncogene·H K EliasU Steidl
Nov 19, 2010·Expert Review of Hematology·Judith NeukirchenUlrich Germing
Feb 17, 2011·Expert Review of Hematology·Eric PadronAlan F List

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