Gene expression profiles of European wild boar naturally infected with Mycobacterium bovis

Veterinary Immunology and Immunopathology
Ruth C GalindoJosé de la Fuente

Abstract

Global gene expression profiles were analyzed in European wild boar naturally infected with Mycobacterium bovis. Spleen RNA was extracted from 23 M. bovis-infected and 17 uninfected animals and analyzed using a Pigoligoarray representing 20,400 genes. Differentially expressed sequences (N=161) were identified affecting cellular processes such as apoptosis, cell communication and signal transduction, cell growth and/or maintenance, cytoskeleton organization and biogenesis, DNA repair, immune response, metabolism and energy pathways, protein metabolism, regulation of cell proliferation, regulation of gene expression, regulation of nucleic acid metabolism, regulation of physiological processes, and transport. Real-time RT-PCR analysis of mRNA levels was used to corroborate microarray results of selected genes. Immune response genes were among the most represented differentially expressed sequences and were selected for further discussion. Beta-defensin 129, T-cell surface glycoprotein CD8 and B-cell receptor-associated protein 29 were overexpressed in infected animals. Lower expression levels of the immune response genes galectin-1, complement component C1qB and certain HLA class I and class II histocompatibility antigens and immu...Continue Reading

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Citations

Mar 29, 2011·Veterinary Microbiology·Christian GortazarJosé de la Fuente
Nov 19, 2010·Medical Hypotheses·José de la FuenteMargarita Villar
Aug 1, 2012·Veterinary Medicine International·Beatriz Beltrán-BeckChristian Gortázar
Jun 13, 2014·Clinical and Vaccine Immunology : CVI·Beatriz Beltrán-BeckChristian Gortázar
Sep 19, 2019·Infection and Immunity·Kathryn WrightKumudika de Silva
Jun 13, 2013·Physiological Genomics·Nikki le RoexEileen G Hoal

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