Gene expression profiling analysis contributes to understanding the association between non-syndromic cleft lip and palate, and cancer

Molecular Medicine Reports
Hongyi WangKai Tao

Abstract

The present study aimed to investigate the molecular mechanisms underlying non‑syndromic cleft lip, with or without cleft palate (NSCL/P), and the association between this disease and cancer. The GSE42589 data set was downloaded from the Gene Expression Omnibus database, and contained seven dental pulp stem cell samples from children with NSCL/P in the exfoliation period, and six controls. Differentially expressed genes (DEGs) were screened using the RankProd method, and their potential functions were revealed by pathway enrichment analysis and construction of a pathway interaction network. Subsequently, cancer genes were obtained from six cancer databases, and the cancer‑associated protein‑protein interaction network for the DEGs was visualized using Cytoscape. In total, 452 upregulated and 1,288 downregulated DEGs were screened. The upregulated DEGs were significantly enriched in the arachidonic acid metabolism pathway, including PTGDS, CYP4F2 and PLA2G16; and transforming growth factor (TGF)‑β signaling pathway, including SMAD3 and TGFB2. The downregulated DEGs were distinctly involved in the pathways of DNA replication, including MCM2 and POLA1; cell cycle, including CDK1 and STAG1; and viral carcinogenesis, including PIK3C...Continue Reading

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Citations

Aug 7, 2019·Birth Defects Research·Ratnam S SeelanRobert M Greene
Jun 26, 2020·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Yuzi XuFuming He
Sep 14, 2017·International Journal of Molecular Medicine·Veronika ŽivicováBarbora Dvořánková
Sep 27, 2018·European Journal of Human Genetics : EJHG·Zahra Razaghi-MoghadamNaser Ansari-Pour
Mar 12, 2021·Frontiers in Genetics·Karlijne IndencleefPeter Claes
Nov 13, 2020·The Journal of Craniofacial Surgery·Ionária O AssisAlexandre R Vieira

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Software Mentioned

Cytoscape
Bioconductor
R
Bioconductor Affy package

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