Gene expression profiling analysis of patients with ankylosing spondylitis

Journal of Spinal Disorders & Techniques
Zhicai ShiMing Li

Abstract

A comprehensive bioinformatics analysis of genes which may have correlations with ankylosing spondylitis (AS). To study the mechanisms of AS by analyzing microarray of GSE25101. AS is an inflammatory arthritis that can lead to chronic pain and disability. GSE25101 was downloaded from Gene Expression Omnibus including 16 AS patients and 16 normal controls. The differentially expressed genes (DEGs) were screened using limma package in Bioconductor and miRNAs targeted DEGs were predicted. Then, gene ontology and pathway enrichment analysis of DEGs was performed using Database for Annotation, Visualization, and Integrated Discovery. Besides, the interaction relationships of the proteins encoded by DEGs were searched by STRING, and the protein-protein interaction (PPI) network was visualized by Cytoscape. Moreover, modules analysis of PPI network was performed using Clique Percolation Method in CFinder. A total of 284 DEGs were screened and 1899 miRNA-mRNA regulatory pairs were obtained. Both myosin heavy chain 9 (MYH9) and B-cell chronic lymphocytic leukemia/lymphoma 11B (BCL11B) were targeted by has-miR-124 and has-miR-363. Function enrichment analyze indicated that these DEGs, especially, downregulated protein tyrosine phosphatas...Continue Reading

References

Apr 28, 1973·Lancet·D A BrewertonR D Sturrock
Nov 19, 1997·Arthritis and Rheumatism·E Märker-HermannG Wildner
Nov 3, 1998·Lancet·D McGonagleP Emery
Mar 23, 2001·Nature Immunology·K S SchlunsL Lefrançois
Oct 31, 2002·Best Practice & Research. Clinical Rheumatology·Muhammad A Khan, Edward J Ball
Jul 9, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hak-Ling MaKyriaki Dunussi-Joannopoulos
Dec 6, 2003·Science·Chang-Zheng ChenDavid P Bartel
Dec 31, 2003·Cell·Benjamin P LewisChristopher B Burge
Jul 6, 2004·Human Molecular Genetics·Corinne Miceli-RichardUNKNOWN Groupe Français d'Etude Génétique des Spondylarthropathies
Sep 14, 2004·Nature Immunology·Hai-Hui XueWarren J Leonard
Feb 7, 2006·Current Biology : CB·Sabbi LallNikolaus Rajewsky
Jan 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ryan M O'ConnellDavid Baltimore
Apr 24, 2007·Lancet·Jürgen Braun, Joachim Sieper
Sep 26, 2007·Nature Genetics·Michael KerteszEran Segal
Oct 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Esmerina TiliCarlo Maria Croce
Dec 26, 2007·Nucleic Acids Research·Doron BetelChris Sander
Apr 9, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mark M PerryMark A Lindsay
May 10, 2008·Bioinformatics·Pan DuSimon M Lin
Oct 17, 2008·PloS One·Ming LuQinghua Cui
Jan 10, 2009·Nature Protocols·Da Wei HuangRichard A Lempicki
Sep 8, 2009·Advances in Experimental Medicine and Biology·Georg Schett
Jan 12, 2010·Nature Genetics·UNKNOWN Australo-Anglo-American Spondyloarthritis Consortium (TASC)Matthew A Brown
Apr 13, 2010·Nature Genetics·Timothy R D J RadstakeMaureen D Mayes
Nov 8, 2012·Nature Methods·Rintaro SaitoTrey Ideker
Dec 4, 2012·Nucleic Acids Research·Andrea FranceschiniLars J Jensen

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Citations

Nov 22, 2017·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Xiang GuJian-Jie Wei

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