PMID: 19942813Nov 28, 2009Paper

Gene expression profiling and cellular distribution of molecules with altered expression in the hippocampal CA1 region after developmental exposure to anti-thyroid agents in rats

The Journal of Veterinary Medical Science
Yukie SaegusaMakoto Shibutani

Abstract

To determine whether developmental hypothyroidism causes permanent disruption of neuronal development, we first performed a global gene expression profiling study targeting hippocampal CA1 neurons in male rats at the end of maternal exposure to anti-thyroid agents on weaning (postnatal day 20). As a result, genes associated with nervous system development, zinc ion binding, apoptosis and cell adhesion were commonly up- or down-regulated. Genes related to calcium ion binding were up-regulated and those for myelination were often down-regulated. We, then, examined immunohistochemical cellular distribution of Ephrin type A receptor 5 (EphA5) and Tachykinin receptor (Tacr)-3, those selected based on the gene expression profiles, in the hippocampal formation at the adult stage (11-week-old) as well as at the end of exposure. At weaning, both EphA5- and Tacr3-immunoreactive cells with strong intensities appeared in the pyramidal cell layer or stratum oriens of the hippocampal CA1 region. Although the magnitude of the change was decreased at the adult stage, Tacr3 in the CA1 region showed a sustained increase in expressing cells until the adult stage after developmental hypothyroidism. On the other hand, EphA5-expressing cells did not...Continue Reading

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Citations

May 15, 2013·The Journal of Toxicological Sciences·Hirotoshi AkaneMakoto Shibutani
Apr 11, 2018·Parasite : Journal De La Société Française De Parasitologie·Melissa J WalkerDanny Haelewaters
Sep 15, 2020·ACS Chemical Neuroscience·Wen-Wen ZhangYu-Xia Chu

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