Gene expression profiling identifies the role of Zac1 in cervical cancer metastasis.

Scientific Reports
Hui-Chen SuShih-Ming Huang

Abstract

The zinc-finger protein which regulates apoptosis and cell cycle arrest 1 (Zac1), encoded by Plagl1 gene, is a seven-zinc-finger containing transcription factor belonging to the imprinted genome and is expressed in diverse types of embryonic and adult human tissues. Zac1 is postulated to be a tumor suppressor by inducing cell cycle arrest and apoptosis through interacting and modulating transcriptional activity of p53 as it was named. Correspondingly, the reduction or loss of Zac1 expression is associated with the incidence and progression of several human tumors, including cervical cancer, breast cancer, ovarian cancer, pituitary tumors, and basal cell carcinoma, implying the rationality of utilizing Zac1 expression as novel a biomarker for the evaluation of cervical cancer prognosis. However, to date, it has not been elucidated whether Zac1 expression is related to the prognosis of patients in clinical cervical cancer tumor samples. To address the questions outlined above, we report here a comprehensive investigation of Zac1 expression in biopsies of clinical cervical carcinoma. By analyzing Zac1 expression in various gene expression profiling of cervical cancer databases, we show the association between high Zac1 expression ...Continue Reading

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Citations

Mar 7, 2021·International Journal of Molecular Sciences·Joanna SobocińskaUrszula Oleksiewicz
Dec 29, 2020·Seminars in Cancer Biology·Urszula Oleksiewicz, Marta Machnik
May 21, 2021·Journal of Inflammation Research·Hsuan-Wei ChenYi-Lin Chiu

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Datasets Mentioned

BETA
GSE68339
GSE7803
GSE9750
GSE63514

Methods Mentioned

BETA
biopsies
profiler
protein assay
RNA-seq
methylation profiling
transfection

Software Mentioned

GSEA
Fiji
ImageJ
CluePedia
Cytoscape ClueGo
Cytoscape
GraphPad Prism
GEOquery package
R
ClueGO

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