Gene expression profiling in autoantibody-positive patients with arthralgia predicts development of arthritis

Arthritis and Rheumatism
L G M van BaarsenC L Verweij

Abstract

To identify molecular features associated with the development of rheumatoid arthritis (RA), to understand the pathophysiology of preclinical development of RA, and to assign predictive biomarkers. The study group comprised 109 anti-citrullinated protein antibody (ACPA)- and/or rheumatoid factor-positive patients with arthralgia who did not have arthritis but were at risk of RA, and 25 patients with RA. The gene expression profiles of blood samples obtained from these patients were determined by DNA microarray analysis and quantitative polymerase chain reaction. In 20 of the 109 patients with arthralgia who were at risk of RA, arthritis developed after a median of 7 months. Gene expression profiling of blood cells revealed heterogeneity among the at-risk patients, based on differential expression of immune-related genes. This report is the first to describe gene signatures relevant to the development of arthritis. Signatures significantly associated with arthritis development were involved in interferon (IFN)-mediated immunity, hematopoiesis, and chemokine/cytokine activity. Logistic regression analysis revealed that the odds ratio (OR) for developing arthritis within 12 months was 21.0 (95% confidence interval [95% CI] 2.8-156...Continue Reading

References

Sep 1, 1987·Annals of the Rheumatic Diseases·F Klein, M B Janssens
May 1, 1985·Arthritis and Rheumatism·K AhoJ T Salonen
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·M B EisenD Botstein
Mar 20, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·T FukaoS Koyasu
Apr 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·V G TusherG Chu
Feb 13, 2002·Arthritis and Rheumatism·James R O'Dell
Apr 16, 2002·Arthritis and Rheumatism·Timo MöttönenUNKNOWN FIN-RACo Trial Group. FINnish Rheumatoid Arthritis Combination therapy
May 16, 2002·Proceedings of the National Academy of Sciences of the United States of America·Robert TibshiraniGilbert Chu
Mar 21, 2003·Biochemical and Biophysical Research Communications·Nobuko FukumaKazuhisa Sekimizu
Jul 9, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jonathan A HillEwa Cairns
Sep 4, 2003·Genome Research·Paul D ThomasApurva Narechania
Oct 15, 2003·Arthritis and Rheumatism·Solbritt Rantapää-DahlqvistWalther J van Venrooij
Jun 18, 2004·The New England Journal of Medicine·Jonathan C W EdwardsTim Shaw
Oct 14, 2004·Annals of the Rheumatic Diseases·L KlareskogL Padyukov
Nov 6, 2004·Arthritis and Rheumatism·Thomas StablerVirginia B Kraus
Apr 6, 2006·The Journal of Clinical Investigation·Kristine A KuhnV Michael Holers
Jul 14, 2006·Genes and Immunity·L G M van BaarsenC L Verweij
Nov 1, 2006·Biochemical Society Transactions·M Pruenster, A Rot
Mar 21, 2007·Annals of Internal Medicine·Yvonne P M Goekoop-RuitermanBen A C Dijkmans
Sep 7, 2007·The New England Journal of Medicine·Elaine F RemmersPeter K Gregersen
Jan 5, 2008·Annual Review of Immunology·Lars KlareskogLars Alfredsson
Apr 9, 2008·The Journal of Experimental Medicine·Jonathan A HillEwa Cairns

❮ Previous
Next ❯

Citations

Dec 10, 2013·Best Practice & Research. Clinical Rheumatology·Kevin D Deane
Dec 10, 2013·Best Practice & Research. Clinical Rheumatology·Edith Villeneuve
Jul 23, 2013·Nature Protocols·Huaiyu MiPaul D Thomas
Jun 15, 2011·Nature Reviews. Rheumatology·Johanna M W Hazes, Jolanda J Luime
May 11, 2013·Annals of the Rheumatic Diseases·L G M van BaarsenP P Tak
Feb 15, 2011·Arthritis Research & Therapy·Mary K Crow
Nov 11, 2010·Arthritis Research & Therapy·Tineke CantaertLisa G M van Baarsen
Jul 31, 2010·Genome Medicine·James N Jarvis, Mark Barton Frank
Feb 12, 2014·Nature Reviews. Rheumatology·Kevin D Deane, Hani El-Gabalawy
Mar 5, 2014·The Pharmacogenomics Journal·A N BurskaF Ponchel
Mar 20, 2014·Current Rheumatology Reports·Kevin D Deane
Jun 18, 2014·Nature Reviews. Rheumatology·Laura Hunt, Paul Emery
Dec 2, 2014·Rheumatic Diseases Clinics of North America·Tabitha N Kung, Vivian P Bykerk
Oct 13, 2012·Pharmacology & Therapeutics·Gianluca GrassiaPasquale Maffia
Mar 11, 2011·Trends in Molecular Medicine·Bertalan MeskoLaszlo Nagy
Jun 1, 2010·Rheumatic Diseases Clinics of North America·Kevin D DeaneV Michael Holers
Aug 7, 2014·Rheumatology·Elizabeth W KarlsonAnnette H van der Helm-van Mil
May 21, 2013·Arthritis and Rheumatism·H W van SteenbergenA H M van der Helm-van Mil
Mar 24, 2016·International Journal of Technology Assessment in Health Care·Leander R BuismanWilliam K Redekop
Jan 28, 2016·Arthritis & Rheumatology·Kulveer Mankia, Paul Emery
Mar 31, 2016·Current Opinion in Rheumatology·Kulveer Mankia, Paul Emery
May 29, 2015·Annals of the Rheumatic Diseases·Joyce LübbersCornelis L Verweij
Apr 5, 2016·Expert Review of Molecular Diagnostics·Ana MárquezF David Carmona
Jan 23, 2014·Annals of the Rheumatic Diseases·Steven GazalPhilippe Dieudé
Mar 21, 2015·BioMed Research International·Francesca BenaglioAntonio Manzo
Jun 12, 2016·Arthritis Research & Therapy·Leander R BuismanMaureen P M H Rutten-van Mölken
May 4, 2017·Antioxidants & Redox Signaling·Outi SareilaRikard Holmdahl
Nov 10, 2017·Nature Reviews. Rheumatology·Hanna W van SteenbergenAnnette H M van der Helm-van Mil
Dec 24, 2017·Arthritis Research & Therapy·L OuboussadM H Buch
May 1, 2015·PloS One·Bernard R LauwerysPierre Dupont
Oct 10, 2018·Annals of the Rheumatic Diseases·Hong ZhuShu-Feng Lei
Nov 3, 2010·Nature Reviews. Rheumatology·David L Scott, Anna Kowalczyk
Sep 29, 2019·Journal of Internal Medicine·S Rantapää Dahlqvist, F Andrade
Dec 3, 2013·Journal of Perinatal Medicine·Ichchha MadanTinnakorn Chaiworapongsa

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cells: Gene Expression

B lymphocytes are white blood cells that play a role in the adaptive immune system by secreting antibodies. Here is the latest research on gene expression in B cells.