Gene expression profiling in male B6C3F1 mouse livers exposed to kava identifies--changes in drug metabolizing genes and potential mechanisms linked to kava toxicity.

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Lei GuoPeter P Fu

Abstract

The association of kava products with liver-related health risks has prompted regulatory action in many countries. We used a genome-wide gene expression approach to generate global gene expression profiles from the livers of male B6C3F1 mice administered kava extract by gavage for 14 weeks, and identified the differentially expressed drug metabolizing genes in response to kava treatments. Analyses of gene functions and pathways reveal that the levels of significant numbers of genes involving drug metabolism were changed and that the pathways involving xenobiotics metabolism, Nrf2-mediated oxidative stress response, mitochondrial functions and others, were altered. Our results indicate that kava extract can significantly modulate drug metabolizing enzymes, potentially leading to herb-drug interactions and hepatotoxicity.

References

Jan 1, 1994·Drug Metabolism Reviews·F J Gonzalez, H V Gelboin
Dec 18, 1998·Deutsche medizinische Wochenschrift·S StrahlK P Maier
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·M Ramos-GomezT W Kensler
Mar 29, 2001·Public Health Nutrition·P L Le Bars, J Kastelan
Apr 5, 2001·Proceedings of the National Academy of Sciences of the United States of America·K ChanY W Kan
Oct 19, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·James M MathewsSherry R Black
Apr 16, 2003·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Judy L Raucy
Dec 12, 2003·Integrative Cancer Therapies·Harry H S Fong
Mar 24, 2004·Biochemical Pharmacology·Dirk RoymansWillem Meuldermans
May 27, 2005·Drugs·Zeping HuShufeng Zhou
Jul 12, 2005·Journal of Ethnopharmacology·Yadhu N Singh
Jan 13, 2006·Annual Review of Pharmacology and Toxicology·Frank J Gonzalez, Ai-Ming Yu
Sep 14, 2006·Annual Review of Pharmacology and Toxicology·Thomas W KenslerShyam Biswal
Oct 25, 2006·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Natasha P ClaytonAbraham Nyska
Nov 3, 2006·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Bill J GurleySreekhar Cheboyina
Mar 17, 2007·Chemical Research in Toxicology·Richard B van BreemenNorman R Farnsworth
Jun 15, 2007·Toxicologic Pathology·Lauren M Aleksunes, José E Manautou
Sep 6, 2007·Drug Metabolism Reviews·Tadeja RezenDamjana Rozman
Oct 22, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yuko YamazakiFumio Shimura
Dec 23, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Lei GuoPeter Fu
Feb 28, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Scott A ReismanCurtis D Klaassen
Feb 28, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Scott A ReismanCurtis D Klaassen
Dec 2, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Lei GuoPeter Fu
Jul 2, 2011·The American Journal of Chinese Medicine·Po-Chuen ChanPeter P Fu

❮ Previous
Next ❯

Citations

Sep 13, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Yan LiLei Guo
Jul 2, 2011·The American Journal of Chinese Medicine·Po-Chuen ChanPeter P Fu
Jan 9, 2016·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Sreekanth C NarayanapillaiChengguo Xing
Feb 9, 2012·Journal of Ethnopharmacology·Olavi PelkonenTai-Ping Fan
Aug 30, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mamta BehlPo C Chan
Apr 27, 2016·Toxicology Letters·Qiangen WuMatthew S Bryant
Apr 20, 2016·International Journal of Molecular Sciences·Flaminia PantanoEnrico Marinelli
Dec 2, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Lei GuoPeter Fu
Jul 16, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Rolf Teschke
Apr 15, 2010·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Lei GuoPeter P Fu
Aug 23, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Gulcin TugcuAhmet Aydın
Sep 4, 2014·Chemical Research in Toxicology·Sreekanth C NarayanapillaiChengguo Xing

❮ Previous
Next ❯

Related Concepts

Related Feeds

Ataxia

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Ataxias (MDS)

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Ataxias

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on different types of ataxias here.

Related Papers

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Lei GuoPeter P Fu
Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie
Natasha P ClaytonAbraham Nyska
Toxicological Sciences : an Official Journal of the Society of Toxicology
Steven T S LimPratibha V Nerurkar
© 2022 Meta ULC. All rights reserved