Gene-expression profiling in pancreatic cancer

Expert Review of Molecular Diagnostics
Pedro P López-Casas, Luís A López-Fernández

Abstract

Pancreatic cancer has one of the worst prognoses, owing principally to a late diagnosis and the absence of good treatments. In the last 5 years, up to 12 molecular pathways involved in pancreatic cancer have been described. Global gene-expression profiling and the use of microarray databases have allowed the identification of hundreds of genes that are differentially expressed in pancreatic cancer. However, validation of these genes as biomarkers for early diagnosis, prognosis or treatment efficacy is still incomplete. Additionally, microRNAs have emerged as a potential source of variation between cancer and normal samples, and several of them have been identified as being deregulated in pancreatic tumors. An integrative point of view in the study of pancreatic cancer that makes use of all the whole-genome technologies has revealed several molecular mechanisms that affect pancreatic cancer development. These results should encourage the use of more personalized medicine in this pathology. Recent developments and future perspectives are discussed.

References

Nov 13, 2001·Oncogene·T Crnogorac-JurcevicN R Lemoine
Apr 12, 2002·The American Journal of Pathology·Christine A Iacobuzio-DonahueRalph H Hruban
May 10, 2002·The American Journal of Pathology·Benoit TerrisNicholas R Lemoine
Jun 27, 2002·Oncogene·Tatjana Crnogorac-JurcevicNicholas R Lemoine
Mar 19, 2003·Cancer Biology & Therapy·Scott E KernCharles J Yeo
Mar 26, 2003·The American Journal of Pathology·Christine A Iacobuzio-DonahueMichael Goggins
Apr 8, 2003·World Journal of Gastroenterology : WJG·Zhi-Jun TanYan Tang
Jan 14, 2004·Molecular & Cellular Proteomics : MCP·N Leigh AndersonAnna Lobley
Feb 5, 2004·Electrophoresis·Liping HuJie Chen
Apr 17, 2004·The Journal of Investigative Dermatology·Sari SuomelaUlpu Saarialho-Kere
May 12, 2004·Cancer Biology & Therapy·N Tjarda Van HeekMichael Goggins
Sep 17, 2004·The New England Journal of Medicine·William R BruggeAndrew L Warshaw
Nov 19, 2004·Neoplasia : an International Journal for Oncology Research·Robert GrützmannHans Detlev Saeger
Feb 26, 2005·Advances in Anatomic Pathology·Anirban MaitraRalph H Hruban
May 4, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Davendra SegaraSusan M Henshall
Nov 16, 2005·Gastroenterology·Tatjana Crnogorac-JurcevicNicholas R Lemoine
May 17, 2006·Genes & Development·Aram F HezelRonald A Depinho
Oct 17, 2006·Expert Opinion on Investigational Drugs·Florian EckelRoland M Schmid
Nov 14, 2006·Nucleic Acids Research·Tanya BarrettRon Edgar
Nov 30, 2006·International Journal of Cancer. Journal International Du Cancer·Shin NakahiraMorito Monden
Dec 7, 2006·International Journal of Cancer. Journal International Du Cancer·Eun Joo LeeThomas D Schmittgen
Dec 13, 2006·Nature Biotechnology·Ron Edgar, Tanya Barrett
Feb 7, 2007·Cancer Research·Chenwei LiDiane M Simeone
Mar 16, 2007·Neoplasia : an International Journal for Oncology Research·Daniel R RhodesArul M Chinnaiyan
Apr 5, 2007·Molecular Cancer Therapeutics·Daruka Mahadevan, Daniel D Von Hoff
May 3, 2007·JAMA : the Journal of the American Medical Association·Mark BloomstonCarlo M Croce
Nov 28, 2007·Annual Review of Pathology·Anirban Maitra, Ralph H Hruban
Dec 20, 2007·American Journal of Clinical Pathology·Hongbing DengFan Lin
Feb 27, 2008·Journal of Cellular and Molecular Medicine·Christian PilarskyRobert Grützmann
Mar 12, 2008·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Jianfeng BaiHideo Nagai
Jun 6, 2008·Proteomics·Johan IngvarssonCarl A K Borrebaeck

❮ Previous
Next ❯

Citations

Oct 28, 2010·Cancer Prevention Research·Young-Joon SurhZigang Dong
Apr 18, 2014·Acta Oncologica·Ciara M KellyDerek G Power
Jun 13, 2015·Molecular Medicine Reports·Dong-Yan HanQing Wei
Jul 23, 2011·Human Pathology·Chanjuan Shi, Ralph H Hruban
Nov 4, 2015·Current Problems in Surgery·Shahid G Farid, Gareth Morris-Stiff
Oct 7, 2016·Advanced Science·Rhonda M JackSunitha Nagrath
Jul 25, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tsz-Lun YeungSamuel C Mok
Mar 29, 2014·Molecular Cancer Research : MCR·Amy S FarrellRosalie C Sears

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.