Gene expression profiling in the discovery, optimization and development of novel drugs: one universal screening platform

Pharmacogenomics
David Bol, Reinhard Ebner

Abstract

With recent advances in robotics and high-content screening and analysis methods, transcriptional profiling can now be utilized as a comprehensive forward chemical genomics platform for drug discovery, lead selection and lead optimization. It can be used to define the state of a cell on the basis of gene networks, and to search for drugs that can shift cellular states in a manner predicted at the genome level to be therapeutically beneficial. The treatment of cells with compounds produces transcriptional 'fingerprints' that reveal mechanism-of-action, and enable discrimination between individual compounds based on drug behaviors important to all phases of drug discovery and development.

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Citations

Jul 2, 2009·Nature Reviews. Drug Discovery·Yan FengJohn A Tallarico
Mar 15, 2011·Bioorganic & Medicinal Chemistry Letters·Emilie AdelinJamal Ouazzani
Mar 20, 2015·Cancer Science·Eishi AshiharaTaira Maekawa
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Sep 7, 2016·Cancers·Benjamin LuTerence J Van Raay

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Methods Mentioned

BETA
PCR

Software Mentioned

Avalon

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