Gene expression profiling in the intact and injured brain following environmental enrichment

Journal of Neuropathology and Experimental Neurology
Kathy KeyvaniWerner Paulus

Abstract

An enriched environment promotes structural changes in both injured and intact brain and improves behavioral performance. In 2 different experimental approaches, the effects of enriched surroundings were analyzed utilizing DNA microarrays. First, gene expression patterns of the sensorimotor cortex and the hippocampus of noninjured adult rats with enriched housing were compared with analogous regions of rats kept in standard cages. Second, circumscribed infarcts affecting the forelimb area of the sensorimotor cortex were induced, and gene expression patterns of the non-necrotic ipsilesional as well as the contralesional homotopic cortex of rats (postlesionally enriched housing versus standard) were analyzed. In the intact brain, the hippocampus, which had 43 upregulations and 15 downregulations showed more changes than the sensorimotor cortex, which had 13 upregulations and 4 downregulations, indicating a greater responsiveness of the hippocampus to environmental stimuli. In the injured brain, enrichment led ipsilesionally to 28 downregulations and 14 upregulations, while in the contralesional cortex, upregulations prevailed with 46 upregulations and 13 downregulations. The larger number of genes responsive to enrichment in the ...Continue Reading

References

May 1, 1985·Annals of Neurology·B D WatsonM D Ginsberg
Nov 1, 1969·The Journal of Comparative Neurology·R N WalshR A Cummins
Jan 1, 1969·Developmental Psychobiology·M R Rosenzweig, E L Bennett
Nov 15, 1993·Biochemical and Biophysical Research Communications·I GiambancoR Donato
Apr 15, 1999·Annual Review of Neuroscience·A K McAllisterD C Lo
Jun 6, 2000·Trends in Neurosciences·S C Cramer, M Chopp
Aug 6, 2000·Journal of Neurogenetics·R R Staples, M Ramaswami
Nov 9, 2000·Proceedings of the National Academy of Sciences of the United States of America·C RamponY Hu
Mar 22, 2001·Nature Reviews. Neuroscience·H van PraagF H Gage
Dec 14, 2001·Neurobiology of Disease·L TongC W Cotman
Jan 25, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Barbro B Johansson, Pavel V Belichenko
Feb 2, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Kathy KeyvaniWerner Paulus
Oct 22, 2002·Journal of Neuropathology and Experimental Neurology·Kathy Keyvani, Timothy Schallert
Jan 3, 2003·Nature Cell Biology·Xiao-bing YuanShumin Duan
Jun 6, 2003·The European Journal of Neuroscience·Jason BrownH Georg Kuhn

❮ Previous
Next ❯

Citations

May 27, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Josefine Nygren, Tadeusz Wieloch
Sep 14, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Mattias RickhagTadeusz Wieloch
Nov 29, 2008·Stroke; a Journal of Cerebral Circulation·Catherine M PapadopoulosWilliam A Wolf
Aug 6, 2019·Frontiers in Cellular Neuroscience·Abdelmoneim EshraStefan Hallermann
Jun 22, 2012·Neural Plasticity·José Fernando Maya-VetencourtLamberto Maffei
Jul 19, 2013·Neural Plasticity·Alessio FaralliDaniela Carulli
Apr 1, 2017·Translational Neurodegeneration·Bin-Yin LiSheng-Di Chen
Nov 12, 2017·Cell and Tissue Research·Brian E Eisinger, Xinyu Zhao
Aug 4, 2018·Frontiers in Behavioral Neuroscience·Susan A RapleyEric A Espiner
Feb 16, 2007·Neuroreport·Jan A JablonkaMałgorzata Kossut
Jan 3, 2014·Physiological Reviews·Alessandro SaleLamberto Maffei
Feb 7, 2019·Nature Reviews. Neuroscience·Gerd Kempermann
Jul 23, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Karsten RuscherTadeusz Wieloch
Feb 1, 2011·Brain : a Journal of Neurology·Karsten RuscherTadeusz Wieloch
Sep 18, 2014·Frontiers in Systems Neuroscience·Dasuni S Alwis, Ramesh Rajan
Dec 20, 2018·Brain Plasticity·María Llorens-Martín
Jul 2, 2020·Journal of Materials Science. Materials in Medicine·Stephanie Sánchez-TorresHermelinda Salgado-Ceballos

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.