Gene expression profiling of asthma phenotypes demonstrates molecular signatures of atopy and asthma control

The Journal of Allergy and Clinical Immunology
Judie A HowrylakEric P Xing

Abstract

Recent studies have used cluster analysis to identify phenotypic clusters of asthma with differences in clinical traits, as well as differences in response to therapy with anti-inflammatory medications. However, the correspondence between different phenotypic clusters and differences in the underlying molecular mechanisms of asthma pathogenesis remains unclear. We sought to determine whether clinical differences among children with asthma in different phenotypic clusters corresponded to differences in levels of gene expression. We explored differences in gene expression profiles of CD4(+) lymphocytes isolated from the peripheral blood of 299 young adult participants in the Childhood Asthma Management Program study. We obtained gene expression profiles from study subjects between 9 and 14 years of age after they participated in a randomized, controlled longitudinal study examining the effects of inhaled anti-inflammatory medications over a 48-month study period, and we evaluated the correspondence between our earlier phenotypic cluster analysis and subsequent follow-up clinical and molecular profiles. We found that differences in clinical characteristics observed between subjects assigned to different phenotypic clusters persist...Continue Reading

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Citations

Jun 11, 2016·Allergology International : Official Journal of the Japanese Society of Allergology·Ioana Agache, Cezmi A Akdis
Jul 30, 2016·Molecular and Cellular Pediatrics·Katja Landgraf-RaufBianca Schaub
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Apr 15, 2021·Cytokine·Espiridión Ramos-MartínezGuillermo Velázquez-Sámano
Jul 7, 2019·The Journal of Allergy and Clinical Immunology·Scott R Tyler, Supinda Bunyavanich
Jun 29, 2021·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Brittany A LeaderDavid F Smith

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