Gene expression profiling of cancer by use of DNA arrays: how far from the clinic?

The Lancet Oncology
François BertucciDaniel Birnbaum

Abstract

DNA arrays allow the simultaneous analysis of expression levels for thousands of genes in normal and pathological tissues and hold great promise in molecular medicine, notably in cancer research. The great biological and clinical diversity present in human tumours is poorly characterised by the current classification systems. DNA arrays can provide a better understanding of oncogenesis, leading to improvements in cancer management. First, the identification of new target genes and pathways will allow the development of specific molecular-based anticancer drugs. Secondly, expression profiles will permit tumour classification in more homogeneous diagnostic and prognostic groups, as well as the identification of new clinically and biologically relevant tumour subclasses. Here, we review the technology and present some cancer studies with promising results. Finally, we discuss some of the issues that must be resolved in the near future, so that DNA arrays can fulfil the aims mentioned above.

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Citations

Jan 8, 2003·Pathology Oncology Research : POR·József TímárLászló Kopper
Jan 28, 2004·Comptes rendus biologies·François BertucciCatherine Nguyen
Jan 28, 2003·The American Journal of Pathology·Thomas J GiordanoSamir M Hanash
Jan 28, 2003·Drug Discovery Today·Karol Sikora
Jul 8, 2008·Médecine sciences : M/S·François BertucciDaniel Birnbaum
Oct 3, 2002·Journal of the National Cancer Institute·François BertucciDaniel Birnbaum
Jul 25, 2009·Obstetrical & Gynecological Survey·Vanessa N HarryDavid E Parkin
Jan 23, 2003·Annals of the New York Academy of Sciences·Francois BertucciCatherine Nguyen
Apr 15, 2008·Future Oncology·François Bertucci, Anthony Goncalves
Apr 15, 2014·Critical Reviews in Oncology/hematology·Renaud SabatierFrançois Bertucci
Nov 3, 2009·The Lancet Oncology·Martine Corrette PloemWim H van Harten
Jun 12, 2004·The Journal of Investigative Dermatology·Rita WongNicholas R Benson
Jan 18, 2008·The Journal of Investigative Dermatology·Mei YuKevin J McElwee
Jun 7, 2005·La Revue de médecine interne·A GonçalvesF Bertucci
Mar 3, 2009·Critical Reviews in Oncology/hematology·Renaud SabatierFrançois Bertucci
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Apr 13, 2012·Médecine sciences : M/S·François Bertucci, Daniel Birnbaum
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Mar 23, 2005·Cancer Research·François BertucciDaniel Birnbaum
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Oct 27, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F BertucciD Birnbaum
Oct 1, 2005·Analytical Chemistry·Maria Lisa Del GialloMarco Mascini

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