Gene expression profiling of gray zone lymphoma.

Blood Advances
Clémentine SarkozyChristian Steidl

Abstract

Gray zone lymphoma (GZL), a B-cell lymphoma with features intermediate between large B-cell lymphoma (LBCL) and classic Hodgkin lymphoma (cHL), is a rare and poorly defined entity. Alongside GZL, a subset of Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL) has been described with polymorphic/GZL-like morphology (polymorphic-EBV-L). To fill the important gap in our understanding of the pathogenic process underlying these entities, we performed a gene expression study of a large international cohort of GZL and polymorphic-EBV-L, combined with cHL and primary mediastinal large B-cell lymphoma (PMBCL) cases. In an unsupervised principal component analysis, GZL cases presented with intermediate scores in a spectrum between cHL and PMBCL, whereas polymorphic-EBV-L clustered distinctly. The main biological pathways underlying the GZL spectrum were related to cell cycle, reflecting tumor cell content, and extracellular matrix signatures related to the cellular tumor microenvironment. Differential expression analysis and phenotypic characterization of the tumor microenvironment highlighted the predominance of regulatory macrophages in GZL compared with cHL and PMBCL. Two distinct subtypes of GZL were distinguishab...Continue Reading

References

Feb 2, 1999·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T RüdigerH K Müller-Hermelink
Jan 12, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·J Youn, M A Lynes
Jun 29, 2005·Histopathology·J F GarcíaM A Piris
Oct 15, 2005·The American Journal of Surgical Pathology·Alexandra Traverse-GlehenElaine S Jaffe
Mar 12, 2010·The New England Journal of Medicine·Christian SteidlRandy D Gascoyne
Aug 9, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Franziska C EberleElaine S Jaffe
Jan 10, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Gabriela GualcoCarlos E Bacchi
Jul 24, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·E EmriE Remenyik
Jul 16, 2014·Blood·Wyndham H WilsonKieron Dunleavy
Feb 2, 2015·Haematologica·Robert KridelRandy D Gascoyne
Jan 29, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sydney DuboisFabrice Jardin
Jun 21, 2017·Journal of Internal Medicine·R RosenquistQ Pan-Hammarström
Jul 6, 2017·The New England Journal of Medicine·Christopher MelaniManali Kamdar
Sep 13, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Fong Chun ChanChristian Steidl
Aug 25, 2018·Journal of Hematology & Oncology·Manfei Si, Jinghe Lang
Nov 1, 2018·The New England Journal of Medicine·Ranjana AdvaniSonali M Smith
Dec 14, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daisuke EnnishiDavid W Scott
Dec 13, 2018·The American Journal of Surgical Pathology·Clémentine SarkozyAlexandra Traverse-Glehen

❮ Previous
Next ❯

Citations

Sep 23, 2020·Blood·Clémentine SarkozyChristian Steidl
Apr 2, 2021·Blood·Elías Campo, Elaine S Jaffe
Jun 28, 2021·Seminars in Diagnostic Pathology·Xiaoqiong WangAndres E Quesada
Jul 9, 2021·Expert Review of Anticancer Therapy·Vincent CamusClémentine Sarkozy
Dec 4, 2021·Leukemia & Lymphoma·Hanno M WitteNiklas Gebauer

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Related Papers

Hematology/oncology Clinics of North America
Monika PilichowskaAndrew M Evens
British Journal of Haematology
Athena KritharisAndrew M Evens
Pediatric Blood & Cancer
Thomas PerweinAustrian Society of Pediatric Hematology and Oncology and the Austrian Berlin-Frankfurt-Münster (BFM) Study Group
© 2022 Meta ULC. All rights reserved