Gene expression profiling of oral squamous cell carcinoma using laser microdissection and cDNA microarray

Medical Electron Microscopy : Official Journal of the Clinical Electron Microscopy Society of Japan
Tarou IriéTetsuhiko Tachikawa

Abstract

Cancer diagnosis and therapy are performed on the basis of clinical stage and clinicopathological findings; however, sensitivity to therapy and prognosis may not always be the same even when considering similar cancers because it is difficult to recognize adequate biological characteristics of a cancer when determining cancer therapy. To enable personalized medicine for cancer diagnosis and therapy, which may solve this problem, we used laser microdissection and cDNA microarrays to study the gene expression profile of oral squamous cell carcinoma. Moreover, to establish an objective evaluation with this system, we examined which type of gene expression profile corresponded to the biological characteristics of this cancer. We identified several genes that were up- or downregulated in the majority of cases and clarified genes sharing common behavioral profiles between metastasis-positive and metastasis-negative cases. It was suspected that the genes that were commonly up- or downregulated in the majority of cases were important for histogenesis and acquisition of invasion and proliferation capability and that the genes sharing common behavioral profiles between metastasis-positive and metastasis-negative cases played a large role...Continue Reading

Citations

May 21, 2008·Archives of Otolaryngology--head & Neck Surgery·Peter ChoiChu Chen
May 31, 2008·Archivum Immunologiae Et Therapiae Experimentalis·Sabine Hombach-KlonischMarek Los
Nov 6, 2009·The Bulletin of Tokyo Dental College·Shinya WatanabeGen-yuki Yamane
Jun 28, 2005·Oral Oncology·Yan WangTetsuhiko Tachikawa
Nov 20, 2013·Clinical Medicine Insights. Oncology·Ahmad A Abdulmajeed, Camile S Farah
Sep 14, 2006·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Andras LadanyiZsolt Tulassay
Jan 12, 2008·Journal of Pharmacological Sciences·Kae TeramotoKatsuyuki Miura

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