Gene expression profiling of ovarian tissues for determination of molecular pathways reflective of tumorigenesis

Journal of Molecular Biology
Jean-Luc C MougeotJames B Hall

Abstract

Ovarian cancer is the fourth leading cause of gynecological cancer death among women in the United States. Early detection is a critical prerequisite to initiating effective cancer therapy. Gene microarray technology and proteomics have provided much of the biomarkers with potential use for diagnosis. However, more research is needed to fully understand disease onset and progression. To this end, we have performed microarray analysis with the goal of identifying molecular interaction networks defining tumor growth. Microarray analysis was performed on a limited set of ovarian tissues with various pathological diagnoses using Human Genome Focus Array (HGFA) for the detection of approximately 8500 human transcripts. Hierarchical clustering identified groups of ovarian tissues reflective of low malignant potential/early cancer onset and possible pre-cancerous stages involving small molecule, cytokine and/or hormone-dependent feed-back responses specific to the pelvic reproductive system and a priori initiated tumor suppression mechanisms. ANOVA followed by post hoc Scheffe confirmed our hypotheses. Moreover, we established a protein/protein interaction database associated with HGFA probe sets. This database was used to build and v...Continue Reading

References

Sep 30, 1992·International Journal of Cancer. Journal International Du Cancer·A C KueselI C Smith
Apr 1, 1997·Genome Research·W YuR A Gibbs
Dec 12, 1997·The American Journal of Clinical Nutrition·L Kohlmeier
Oct 29, 1998·The Journal of Biological Chemistry·M SchraderS J Gould
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·M B EisenD Botstein
Dec 10, 1998·The American Journal of Pathology·C TomasettoM C Rio
Oct 21, 1999·Journal of Cellular Physiology·Y ChenH K Chew
Jan 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A SicaA Mantovani
Mar 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·M D MegonigalC A Felix
Jun 22, 2000·Journal of Cardiopulmonary Rehabilitation·A H Lichtenstein
Jun 30, 2000·The Journal of Biological Chemistry·D L SegevS Maheswaran
Sep 13, 2000·Biological Research·A Valenzuela, N Morgado
Nov 9, 2000·Proceedings of the National Academy of Sciences of the United States of America·R CalvoH A Drabkin
Jan 3, 2001·Proceedings of the National Academy of Sciences of the United States of America·C Li, W H Wong
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·S. O'TooleJ. Bonnar
Mar 10, 2001·International Journal of Cancer. Journal International Du Cancer·J G HengstlerB Tanner
Jun 23, 2001·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Y ItohS Mizuno
Aug 4, 2001·The American Journal of Pathology·G de PinieuxM F Poupon
Dec 26, 2001·EMBO Reports·Frank J T StaalHans C Clevers
Jan 5, 2002·Nutrition and Cancer·M L SlatteryJ D Potter
Apr 27, 2002·The Journal of Biological Chemistry·Veronique GigouxChristiane Garbay
Jun 28, 2002·Cancer Cell·Ashani T WeeraratnaJeffrey M Trent
Oct 18, 2002·Journal of Cellular Physiology·Rakesh Kumar, Ratna K Vadlamudi
Jan 17, 2003·The Journal of Biological Chemistry·Lilian L SoonKam-Meng Tchou-Wong
Jun 6, 2003·The Journal of Biological Chemistry·Joanna K Sax, Wafik S El-Deiry
Jul 30, 2003·Cancer Metastasis Reviews·Hiroshi KatayamaSubrata Sen
Sep 13, 2003·The Journal of Clinical Endocrinology and Metabolism·Anne E NelsonPhillip Clifton Bligh
Oct 2, 2003·Genome Biology·Douglas A HosackRichard A Lempicki
Oct 2, 2003·International Journal of Cancer. Journal International Du Cancer·Christer BorgfeldtBertil Casslén
Oct 11, 2003·The International Journal of Biological Markers·S E TheocharisA Koutselinis

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Citations

Jan 20, 2007·Omics : a Journal of Integrative Biology·Nabil BelacelMiroslava Cuperlovic-Culf
Jan 26, 2008·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·B GyörffyH Lage
Aug 23, 2011·International Journal of Cancer. Journal International Du Cancer·Tibor FeketeBalázs Györffy
Sep 4, 2007·The Oncologist·Rudolf S N FehrmannAnne P G Crijns
Aug 25, 2018·Journal of Hematology & Oncology·Manfei Si, Jinghe Lang
Jan 11, 2020·Journal of the American Statistical Association·Kin Yau WongD Y Lin

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