Gene expression profiling of porokeratosis

Journal of Cutaneous Pathology
Zheng-Hua ZhangZhi-Zhong Zheng

Abstract

Porokeratosis (PK) represents a heterogeneous group of disorders of keratinization and has a wide variety of clinical manifestations. PK may exhibit similarities with psoriasis at both clinical and molecular levels. The genetic basis and pathogenesis for PK remain elusive. We studied the transcriptional profiles of three pairwise lesional and uninvolved skin biopsies from patients with different subtypes of PK using the Illumina BeadArray platform. A total of 37 upregulated genes were identified in our study, including wound-induced keratins, S100 calcium-binding protein genes involved in epidermal differentiation, as well as genes involved in mediating intercellular communication and the immune response. To our knowledge, this is the first study that characterizes the immune profile of PK lesions. Here, we report that keratinocytes (KCs)-harboring lesions have activated and overexpressed wound-induced keratin genes, which appear to be coregulated with other genes involved in mediating epidermal differentiation, intercellular communication and immunity. This study, from the perspective of gene profiling, supports that gene misregulation in PK mimics that of psoriasis. Our data indicate that the genes implicated in the T-cell-me...Continue Reading

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Citations

Jan 23, 2009·Journal of Human Genetics·Takashi ShiinaJerzy K Kulski
Jul 24, 2015·ELife·Zhenghua ZhangZhengwen Jiang
Jun 11, 2009·Journal of Cutaneous Pathology·Daniel D Miller, Beth S Ruben
Aug 11, 2010·The Australasian Journal of Dermatology·Ericson L GutierrezAlex G Ortega-Loayza
Jul 21, 2009·Journal of Cutaneous Pathology·Zheng-Hua ZhangZhi-Zhong Zheng
Sep 13, 2017·Archives of Dermatological Research·Kanako MatsuyamaMariko Seishima

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