Gene expression profiling of scrapie-infected brain tissue

Biochemical and Biophysical Research Communications
Constanze RiemerM Baier

Abstract

The underlying pathomechanisms in prion infections of the central nervous system are still insufficiently understood. The identification of genes with altered expression patterns in the diseased brain may provide insight into the disease development on the molecular level, which ultimately leads to neuronal loss. To provide a detailed analysis of changes in the molecular level in prion disease pathology we used a large-scale gene array based approach, which covers more than 11,000 functionally characterised sequences and expressed sequence tags, for the analysis of gene expression profile alterations in the cortex, medulla, and pons of scrapie-infected mice. The study identified in total 114 genes with altered mRNA levels, the majority of which were previously not known to be affected by the disease. Overall the gene array data demonstrate the presence of a strong inflammatory reaction and stress response, and show similarities to gene expression patterns found in brains affected by Alzheimer's disease and aging, respectively.

References

Jul 1, 1969·The Journal of General Virology·E J FieldA Keith
Jun 1, 1983·The Journal of General Virology·I GresserR L Chandler
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·M SimonsK Simons
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·S B Prusiner
Jan 23, 1999·Nature Genetics·R J LipshutzD J Lockhart
Apr 30, 1999·Progress in Neurobiology·W J StreitN A Pennell
Mar 4, 2000·The Journal of Pathology·V BeringueD Dormont
Jul 11, 2000·Nature Genetics·C K LeeT A Prolla
Oct 12, 2000·Journal of Virology·C RiemerM Baier
Mar 14, 2001·Brain Research. Brain Research Reviews·P Rezaie, P L Lantos
Mar 29, 2001·Journal of Neuropathology and Experimental Neurology·D T WalshV H Perry
Sep 8, 2001·Progress in Brain Research·U OttenS Rose-John
Dec 12, 2001·Respiration Physiology·J W Deitmer
Feb 16, 2002·The EMBO Journal·Jun TanMike Mullan
Sep 6, 2002·Journal of Alzheimer's Disease : JAD·Shuguang Zhang, Sabina Janciauskiene
Nov 8, 2002·Trends in Molecular Medicine·Patrick L McGeer, Edith G McGeer
Jan 8, 2003·The Journal of Cell Biology·Robert EhehaltKai Simons
Feb 8, 2003·Biochimica Et Biophysica Acta·Izabella Z A PawluczykKevin P G Harris
Feb 26, 2003·Neurobiology of Aging·M Axel WollmerAndreas Papassotiropoulos
Mar 5, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·John F Oram
Jul 9, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yi-Wen LiuWen-Chang Chang
Jul 17, 2003·The Journal of Biological Chemistry·Adrian R WalmsleyNigel M Hooper
Sep 12, 2003·Trends in Pharmacological Sciences·Hua CaiDavid G Harrison
Oct 3, 2003·Ageing Research Reviews·Hiroshi Nakanishi

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Citations

Sep 15, 2009·The Journal of Biological Chemistry·Christian BachIna Vorberg
Dec 22, 2009·Animal Biotechnology·J LyahyaiI Martin-Burriel
Aug 22, 2009·Journal of Toxicology and Environmental Health. Part a·Sarah MedinaStephanie A Booth
Jan 11, 2011·Journal of Toxicology and Environmental Health. Part a·Luciane M AlmeidaLe Luo Guan
Jan 11, 2011·Journal of Toxicology and Environmental Health. Part a·Laura R MoodyJudd M Aiken
Oct 10, 2008·Journal of Virology·Constanze RiemerMichael Baier
May 17, 2006·BMC Genomics·Pamela J SkinnerAshley T Haase
Jan 1, 2008·Advances and Applications in Bioinformatics and Chemistry : AABC·Hyeon O KimPamela J Skinner
Jan 25, 2013·Viruses·Barry M Bradford, Neil A Mabbott
Nov 25, 2014·Viruses·Samia HannaouiSabine Gilch
Feb 1, 2008·Expert Opinion on Medical Diagnostics·Alexander H PedenJames Ironside
Feb 1, 2010·Expert Opinion on Drug Discovery·Federico BenettiGiuseppe Legname
Jul 27, 2011·Comparative Immunology, Microbiology and Infectious Diseases·Denise M NewsomRobert D Harrington
Jun 1, 2011·Environment International·Jack A HeinemannDavid Quist
Jul 30, 2008·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Michael BaierReinhard Schliebs
Dec 18, 2007·Journal of Molecular Biology·Christian JuliusAdriano Aguzzi
Jul 29, 2005·Annals of Neurology·Wei XiangHans A Kretzschmar
Jul 31, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·R EngelsteinR Gabizon
Jun 29, 2007·The European Journal of Neuroscience·Tamara Martínez, Angel Pascual
Nov 27, 2007·Journal of Neurochemistry·Carlo FasanoChiara Zurzolo
Mar 25, 2009·Molecular Systems Biology·Daehee HwangLeroy E Hood
Jul 5, 2005·Biochemical and Biophysical Research Communications·Alan R BrownJohn K Fazakerley

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