Gene expression profiling of sex differences in HIF1-dependent adaptive cardiac responses to chronic hypoxia

Journal of Applied Physiology
Romana BohuslavováG Pavlinkova

Abstract

Although physiological responses to chronic hypoxia, including pulmonary hypertension and right ventricular hypertrophy, have been well described, the molecular mechanisms involved in cardiopulmonary adaptations are still not fully understood. We hypothesize that adaptive responses to chronic hypoxia are the result of altered transcriptional regulations in the right and left ventricles. Here we report results from the gene expression profiling of adaptive responses in a chronically hypoxic heart. Of 11 analyzed candidate genes, the expression of seven and four genes, respectively, was significantly altered in the right ventricle of hypoxic male and female mice. In the transcriptional profile of the left ventricle, we identified a single expression change in hypoxic males (Vegfa gene). To directly test the role of HIF1, we analyzed the expression profile in Hif1a partially deficient mice exposed to moderate hypoxia. Our data showed that Hif1a partial deficiency significantly altered transcriptional profiles of analyzed genes in hypoxic hearts. The expression changes were only detected in two genes in the right ventricle of Hif1a(+/-) males and in one gene in the right ventricle of Hif1a(+/-) females. First, our results suggest t...Continue Reading

References

Aug 14, 1996·Biochemical and Biophysical Research Communications·C M WienerG L Semenza
Apr 1, 1996·Pflügers Archiv : European journal of physiology·P SandnerA Kurtz
Oct 1, 1998·The American Journal of Physiology·A Y YuG L Semenza
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·H H Marti, W Risau
Jun 19, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·L A ShimodaJ T Sylvester
Jan 17, 2002·Proceedings of the National Academy of Sciences of the United States of America·David D KlineNanduri R Prabhakar
Jul 12, 2003·High Altitude Medicine & Biology·Raymond D GilbertLawrence D Longo
Sep 18, 2003·Nature Reviews. Cancer·Gregg L Semenza
Nov 25, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Saumya SharmaM Faadiel Essop
Dec 30, 2004·Journal of Molecular and Cellular Cardiology·Keith A WebsterNanette H Bishopric
Dec 6, 2005·Journal of the American College of Cardiology·Masakuni KidoPatricia A Thistlethwaite
Apr 6, 2006·Biochemical and Biophysical Research Communications·Paola BianciardiMichele Samaja
Apr 20, 2007·Respiratory Physiology & Neurobiology·B Ostadal, F Kolar
Apr 21, 2007·BMC Bioinformatics·Yann KarlenNicolas Mermod
May 1, 2007·Cardiovascular Research·Elizabeth Murphy, Charles Steenbergen
Oct 11, 2007·Science's STKE : Signal Transduction Knowledge Environment·Gregg L Semenza
Jul 25, 2008·The Biochemical Journal·Niall Steven Kenneth, Sonia Rocha
Jun 24, 2009·Experimental Biology and Medicine·Bohuslav OstadalIvana Ostadalova
Feb 19, 2010·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Xianjie ZhangGregg L Semenza

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Citations

May 3, 2013·Pflügers Archiv : European journal of physiology·Martina KlevstigJiri Novotny
Jun 8, 2012·Cardiology in Review·Satwat Hashmi, Suhail Al-Salam
Jan 24, 2013·PloS One·Valeria ParenteMaurizio C Capogrossi
Feb 5, 2016·Molecular Neurobiology·Romana BohuslavovaGabriela Pavlinkova
Jun 14, 2013·Cell Biochemistry and Function·Andrea B ZepedaJorge G Farías
Apr 27, 2013·Journal of Molecular and Cellular Cardiology·Romana BohuslavovaGabriela Pavlinkova
Sep 10, 2015·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Qianqian GaoXu Ma
Jun 16, 2015·Reproductive Toxicology·Romana BohuslavovaGabriela Pavlinkova
Feb 8, 2014·BMC Endocrine Disorders·Romana BohuslavovaGabriela Pavlinkova
May 14, 2018·Cardiovascular Diabetology·Radka CerychovaGabriela Pavlinkova
Nov 21, 2013·American Journal of Respiratory and Critical Care Medicine·Molly K BallPaul T Schumacker
May 2, 2017·Canadian Journal of Physiology and Pharmacology·Petra MíčováMarkéta Hlaváčková
May 2, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Wenjuan LiuTianyou Hu
Apr 27, 2018·Nature Communications·Ana VujicAnthony Rosenzweig
Jul 14, 2019·Molecular and Cellular Biochemistry·Daniel BenakMarketa Hlavackova
Dec 11, 2019·Journal of Tissue Engineering and Regenerative Medicine·Jose Francisco IslasRobert J Schwartz
Aug 31, 2018·Frontiers in Cardiovascular Medicine·Jose L Izquierdo-GarciaJesus Ruiz-Cabello
Nov 4, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Andrea L FrumpTim Lahm
Dec 1, 2020·Respiratory Physiology & Neurobiology·Shrilaxmi Bagali, Kusal K Das
Aug 10, 2021·Frontiers in Cardiovascular Medicine·Shin Mei ChanAlan Dardik

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