Gene expression responses linked to reproduction effect concentrations (EC 10,20,50,90) of dimethoate, atrazine and carbendazim, in Enchytraeus albidus.

PloS One
Sara C NovaisMónica J B Amorim

Abstract

Molecular mechanisms of response to pesticides are scarce and information on such responses from soil invertebrates is almost inexistent. Enchytraeus albidus (Oligochaeta) is a standard soil ecotoxicology model species for which effects of many pesticides are known on survival, reproduction and avoidance behaviour. With the recent microarray development additional information can be retrieved on the molecular effects. Experiments were performed to investigate the transcription responses of E. albidus when exposed to three pesticides - dimethoate (insecticide), atrazine (herbicide) and carbendazim (fungicide) - in a range of concentrations that inhibited reproduction by 10%, 20%, 50% and 90% (EC(10), EC(20), EC(50) and EC(90), respectively). The goal of this study was to further identify key biological processes affected by each compound and if dose-related. All three pesticides significantly affected biological processes like translation, regulation of the cell cycle or general response to stress. Intracellular signalling and microtubule-based movement were affected by dimethoate and carbendazim whereas atrazine affected lipid and steroid metabolism (also by dimethoate) or carbohydrate metabolism (also by carbendazim). Response...Continue Reading

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Citations

Aug 29, 2013·Environmental Toxicology and Chemistry·Sara C Novais, Mónica J B Amorim
Jun 14, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Yuanxiang JinZhengwei Fu
Feb 24, 2015·Environmental Toxicology and Chemistry·Min QiaoYong-Guan Zhu
May 7, 2015·Environmental Toxicology and Chemistry·Ana L Patrício SilvaMartin Holmstrup
Jan 16, 2020·Environmental Science and Pollution Research International·Bina Rai, Steven Don Mercurio
Nov 30, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Cuiyuan JinYuanxiang Jin
Apr 16, 2017·Environmental Toxicology and Chemistry·Diogo N CardosoSusana Loureiro
Apr 25, 2018·Ecology and Evolution·Tjalf E de BoerMónica J B Amorim
Feb 8, 2019·Chemosphere·Fernanda Benedet de SantoJúlia Carina Niemeyer

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Datasets Mentioned

BETA
GPL14928
GSE33945

Methods Mentioned

BETA
electrophoresis
Fluorescence
Feature Extraction
PCR

Software Mentioned

Blast2GO
Basic Local Alignment Search Tool ( BLAST )
Oligo ExplorerTM
Relative Expression Software Tool ( REST - MSC )
Feature Extraction
MultiExperiment Viewer ( MeV
BLASTX

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