Gene expression responses to Zika virus infection in peripheral blood mononuclear cells from pregnant and non-pregnant women.

MicrobiologyOpen
Shen Jean LimMaureen Groer

Abstract

Congenital Zika syndrome is caused by mother-to-fetus transmission of the Zika virus (ZIKV). Peripheral blood mononuclear cells (PBMCs) are permissive to ZIKV infection and may carry ZIKV to the placenta. To identify pregnancy-related differences in PBMC responses against ZIKV infection, we compared gene expression profiles of ZIKV-infected and non-infected PBMCs cultured from pregnant and non-pregnant women. ZIKV-infected pregnant conditions generally overexpressed M1-shifted pro-inflammatory responses and underexpressed M2-shifted anti-inflammatory responses. Additionally, transcripts involved in osteoclast differentiation and cardiac myopathies were upregulated following ZIKV infection. Our results suggest potential roles of pregnancy-induced immune dysregulation in shaping neonatal pathology associated with ZIKV infection.

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Methods Mentioned

BETA
density gradient purification
Light microscopy
PCA
MDS
flow cytometry
flow
PCR

Software Mentioned

Ensembl
RNASeqPower R package
R
ABIS
KEGG mapper
GeneCard
ABsolute Immune Signal ( ABIS )
Spliced
edgeR
SAMtools

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