Gene expression signature and the prediction of lymph node metastasis in colorectal cancer by DNA microarray

Diseases of the Colon and Rectum
Toshiaki WatanabeHirokazu Nagawa

Abstract

Lymph node metastasis is an important factor in determining the outcome of colorectal cancer. If we can predict the presence of lymph node metastasis before surgery, it may help in deciding the need for surgical lymph node dissection or additional preoperative treatment modalities that might improve survival. Our objective here was to identify a set of discriminating genes that can be used for characterization and prediction of lymph node metastasis. Eighty-nine colorectal cancer patients were studied. Gene expression profiles of cancer were determined by human U133 Plus 2.0 GeneChip, and patients with and without lymph node metastasis were compared. We identified 73 novel discriminating genes in which expression was significantly different between patients with and without lymph node metastasis. Using this gene set, we were able to establish a new model to predict the presence of lymph node metastasis with an accuracy of 88.4%. Discriminating genes were associated with various functions, including receptor activity and transcription regulatory activity. The list of genes included transmembrane glycoprotein, which has been reported to have a close relationship with lymph node metastasis in prostate cancer. Transmembrane glycopr...Continue Reading

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Citations

Jun 12, 2012·Cancer Metastasis Reviews·Jinchun Yan, Qihong Huang
Sep 29, 2011·The Journal of Clinical Investigation·James C LeeKenneth G C Smith
Nov 13, 2010·World Journal of Gastroenterology : WJG·Hao WangFu-Ao Cao
Jul 6, 2014·Virchows Archiv : an International Journal of Pathology·Gerardo BottiMonica Cantile
May 19, 2012·Diseases of the Colon and Rectum·Matthew F KaladyJames M Church
Sep 26, 2014·World Journal of Gastroenterology : WJG·Jia-Ding MaoGuang Yang
Nov 7, 2019·Clinical & Experimental Metastasis·Louise van der WeydenGeoffrey A Wood
Dec 12, 2018·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·Pridvi KandagatlaKarin M Hardiman

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