Gene-expression signature predicts survival benefit from postoperative chemoradiotherapy in head and neck squamous cell carcinoma

Oncology Letters
Jin ChenZhaohui Wang

Abstract

Postoperative radiotherapy or concurrent chemoradiotherapy are routine clinical options for the treatment of head and neck squamous cell carcinoma (HNSCC). However, the benefit of adding chemotherapy to radiotherapy is contested. The present study aimed to develop a gene signature to predict the clinical benefit of postoperative chemoradiotherapy using public data from The Cancer Genome Atlas. A 22-gene signature was established, which demonstrated the best predictive value. Patients were separated into low-score and high-score subgroups based on the expression score of the 22-gene signature. In the high-score subgroup, patients who received chemoradiotherapy demonstrated improved overall survival, relapse-free survival and local regional control compared with those who received radiotherapy alone. However, in the low-score subgroup adding chemotherapy to radiotherapy was associated with worse patient outcomes. The predictive value of the 22-gene signature was independent of the conventional clinical variables. Gene set enrichment analysis revealed that the expression signatures of hypoxia phenotype and stem-like traits were significantly enriched in the low-score subgroup. In addition, the low-score subgroup was associated wit...Continue Reading

References

May 7, 2004·The New England Journal of Medicine·Jay S CooperUNKNOWN Radiation Therapy Oncology Group 9501/Intergroup
Oct 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aravind SubramanianJill P Mesirov
Oct 22, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·François JanotJean Bourhis
Dec 25, 2008·Journal of Cancer Research and Clinical Oncology·Hendrik Andreas WolffHans Christiansen
Sep 9, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dennis Shin-Shian HsuMuh-Hwa Yang
Sep 9, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Chang-Qi ZhuMing-Sound Tsao
May 24, 2011·Molecular Cancer·Masanao TabuseMasahiro Toda
May 25, 2011·Nature Reviews. Cancer·William R Wilson, Michael P Hay
Mar 29, 2013·Proceedings of the National Academy of Sciences of the United States of America·De-Chen LinH Phillip Koeffler
Aug 26, 2014·Molecular Cancer Research : MCR·Ginny L PowersPaul C Marker
May 23, 2015·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Helena DoktorovaTomas Eckschlager
Jun 23, 2015·International Journal of Cancer. Journal International Du Cancer·Gunnar WichmannUNKNOWN Leipzig Head and Neck Group (LHNG)
Jan 13, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Annett LingeUNKNOWN DKTK-ROG
Jan 6, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal

❮ Previous
Next ❯

Citations

Jan 29, 2020·Cancers of the Head & Neck·Mara S SerafiniCarlo Resteghini

❮ Previous
Next ❯

Related Concepts