Gene expression study of IL10 family genes in vitiligo skin biopsies, peripheral blood mononuclear cells and sera

The British Journal of Dermatology
R RätsepS Kõks

Abstract

Vitiligo is a pigmentation disorder, the cause of which is complex and not yet fully understood. There is a significant change of epidermal cytokines in involved skin of patients with vitiligo compared with uninvolved skin and skin of healthy controls, thus suggesting a possible involvement of cytokines in the pathogenesis of vitiligo. To evaluate potential roles of IL10 family cytokines (IL10, IL19, IL20, IL22 and IL24) in vitiligo. Along with the selected cytokines, we investigated subunits of the receptors (IL10RA, IL10RB, IL20RA and IL22RA1) which are involved in the signalling pathway of the cytokines. Quantitative real-time polymerase chain reaction was used to detect mRNA expression levels in samples extracted from skin biopsies and peripheral blood mononuclear cells and an enzyme-linked immunosorbent assay was used to measure protein concentrations in serum from patients with vitiligo and healthy controls. IL22 is significantly associated with vitiligo, especially with the active stage of vitiligo, as shown by results of mRNA expression and supported by results of protein level in sera. IL22 may provoke inflammation which leads to destruction of melanocytes. The actual role of IL22 during pathogenesis of vitiligo remain...Continue Reading

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Citations

Sep 16, 2015·Expert Opinion on Pharmacotherapy·Torello LottiGiuseppe Fabrizi
Feb 3, 2011·Translational Oncology·Pascal GelebartRaymond Lai
Dec 25, 2013·The Journal of Investigative Dermatology·Shilpak ChatterjeeShikhar Mehrotra
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Mar 6, 2018·Journal of Cosmetic Dermatology·Sushama SushamaAnubhuti Anubhuti
Dec 6, 2018·Frontiers in Immunology·Liisi RaamKülli Kingo

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