PMID: 15374210Sep 1, 1995Paper

Gene expressions of cholecystokinin (CCK) and CCK receptors, and its satiety effect in young and old male rats

Archives of Gerontology and Geriatrics
K MiyasakaA Funakoshi

Abstract

Cholecystokinin (CCK), one of the first discovered gastrointestinal hormones, which stimulates pancreatic enzyme secretion and induces gallbladder contraction, is one of the most abundant neurotransmitter peptides in the brain and is implicated in satiety via CCK-A receptors. We compared the suppressive effect of central administration of CCK on food intake in young and old rats. The suppressive effect on food intake was enhanced in old rats. To examine the mechanism of this enhanced suppression, we measured the mRNA levels of CCK, CCK-A and CCK-B receptors in the cerebral cortex and the hypothalamus of young and old male rats. The mRNA level of CCK-A receptors in the hypothalamus decreased with age, whereas the mRNA levels of CCK-B receptors in the hypothalamus and cerebral cortex did not. The mRNA level of CCK in the cerebral cortex decreased significantly in old rats, although the decrease in the hypothalamus was not significant. Therefore, the enhanced sensitivity to CCK of old rats could not be explained by changes in gene expressions of CCK and CCK receptors. Moreover, the effects of aging on the gene expressions of CCK-A and CCK-B receptors were different.

References

Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S A WankT Slattery
Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S A WankA de Weerth
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J HughesG N Woodruff
Jan 1, 1991·Progress in Neurobiology·A J Silver, J E Morley
Jan 1, 1988·Neurobiology of Aging·J E Morley, A J Silver
Jan 1, 1986·Brain Research·T H MoranP R McHugh
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R S Chang, V J Lotti
Apr 1, 1994·Journal of Gastroenterology·A FunakoshiA Kono
Sep 1, 1995·Archives of Gerontology and Geriatrics·K MiyasakaA Funakoshi

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Citations

Oct 6, 1995·Neuroscience Letters·M OhtaA Funakoshi
Jun 23, 1999·Nutrition·J E Morley, D R Thomas
Jul 16, 2010·Geriatrics & Gerontology International·Saeko Akimoto, Kyoko Miyasaka
Aug 2, 2015·Age·Adam WysokińskiTomasz Kostka
Jun 5, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Shigeki NomotoKyoko Miyasaka
Dec 1, 2006·The Journal of Physiological Sciences : JPS·Chihiro SakuraiKyoko Miyasaka
Jul 24, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Saeko TakanoKyoko Miyasaka

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