Gene expressions of oxytocin and oxytocin receptor in cumulus cells of human ovary

Hormone Research
K FuruyaK Seki

Abstract

Oxytocin (OT) has been detected in mammalian granulosa-luteal cells during the early stages. The purpose of this study was to explore gene expressions of OT and OT receptor (OTR) in human cumulus cells. Cumulus cells enclosing a mature oocyte were obtained from 6 women undergoing clinical in vitro fertilization and embryo transfer programs. OT and OTR gene expressions were investigated by employing reverse transcription polymerase chain reaction and reverse transcription polymerase chain reaction/single-strand conformation polymorphism methods. OT gene expression in the cumulus cells was positive in 5 women and weakly positive in the remaining patient. The structure of OT mRNA in the cumulus cells was equivalent to that in human hypothalamus. OTR gene expression was also observed in the cumulus cells. This study is the first to describe the simultaneous expression of both OT and OTR genes in human cumulus cells. It is suggested that local OT plays some important roles in fertility through modification of the micro-environment around the oocyte.

Citations

Apr 20, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·D VinatierP Dufour
Jan 9, 2007·Reproductive Biomedicine Online·G KunzG Leyendecker
May 23, 2013·Reproduction in Domestic Animals = Zuchthygiene·M P De CesaroP B Gonçalves
Jul 25, 2019·Frontiers in Endocrinology·Konstantin Bagnjuk, Artur Mayerhofer
Nov 20, 2016·Hormone Molecular Biology and Clinical Investigation·Ez-Zoubir Amri, Didier F Pisani
Mar 29, 2001·Physiological Reviews·G Gimpl, F Fahrenholz
Dec 29, 2020·Reproductive Biomedicine Online·Liliane Fabio Isidoro da SilvaPaula Andrea Navarro

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