Gene family innovation, conservation and loss on the animal stem lineage

ELife
Daniel J RichterNicole King

Abstract

Choanoflagellates, the closest living relatives of animals, can provide unique insights into the changes in gene content that preceded the origin of animals. However, only two choanoflagellate genomes are currently available, providing poor coverage of their diversity. We sequenced transcriptomes of 19 additional choanoflagellate species to produce a comprehensive reconstruction of the gains and losses that shaped the ancestral animal gene repertoire. We identified ~1944 gene families that originated on the animal stem lineage, of which only 39 are conserved across all animals in our study. In addition, ~372 gene families previously thought to be animal-specific, including Notch, Delta, and homologs of the animal Toll-like receptor genes, instead evolved prior to the animal-choanoflagellate divergence. Our findings contribute to an increasingly detailed portrait of the gene families that defined the biology of the Urmetazoan and that may underpin core features of extant animals.

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Citations

Jul 4, 2018·ELife·Zachary R Lewis, Casey W Dunn
Oct 4, 2018·Molecular Biology of the Cell·David S BoothNicole King
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Datasets Mentioned

BETA
PRJNA420352
PRJNA419411

Methods Mentioned

BETA
cDNA library
scraping
chips
Assay
chip
Illumina sequencing

Software Mentioned

Reptile
Mesquite
Cluster
JalView
Archaeopteryx
RStudio
seq
Trinity assembler
Phobius
Transdecoder

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