Gene-flow from steppe individuals into Cucuteni-Trypillia associated populations indicates long-standing contacts and gradual admixture.

Scientific Reports
Alexander ImmelBen Krause-Kyora

Abstract

The Cucuteni-Trypillia complex (CTC) flourished in eastern Europe for over two millennia (5100-2800 BCE) from the end of the Neolithic to the Early Bronze Age. Its vast distribution area encompassed modern-day eastern Romania, Moldova and western/central Ukraine. Due to a lack of existing burials throughout most of this time, only little is known about the people associated with this complex and their genetic composition. Here, we present genome-wide data generated from the skeletal remains of four females that were excavated from two Late CTC sites in Moldova (3500-3100 BCE). All individuals carried a large Neolithic-derived ancestry component and were genetically more closely related to Linear Pottery than to Anatolian farmers. Three of the specimens also showed considerable amounts of steppe-related ancestry, suggesting influx into the CTC gene-pool from people affiliated with, for instance, the Ukraine Mesolithic. The latter scenario is supported by archaeological evidence. Taken together, our results confirm that the steppe component arrived in eastern Europe farming communities maybe as early as 3500 BCE. In addition, they are in agreement with the hypothesis of ongoing contacts and gradual admixture between incoming step...Continue Reading

References

Dec 30, 2006·PLoS Genetics·Nick PattersonDavid Reich
Aug 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·Adrian W BriggsSvante Pääbo
Aug 4, 2009·Genome Research·David H AlexanderKenneth Lange
Jan 19, 2010·Bioinformatics·Heng Li, Richard Durbin
Oct 25, 2011·Nucleic Acids Research·Martin KircherMatthias Meyer
Sep 11, 2012·Genetics·Nick PattersonDavid Reich
Apr 25, 2013·Bioinformatics·Hákon JónssonLudovic Orlando
May 23, 2013·Human Mutation·Dario VianelloClaudio Franceschi
Sep 11, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jesse DabneyMatthias Meyer
Dec 10, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Nadin RohlandDavid Reich
Nov 26, 2015·Nature·Iain MathiesonDavid Reich
May 3, 2016·Nature·Qiaomei FuDavid Reich
Feb 23, 2017·Proceedings of the National Academy of Sciences of the United States of America·Amy GoldbergMattias Jakobsson
Jan 18, 2018·Nature Ecology & Evolution·Åshild J VågeneJohannes Krause
Feb 22, 2018·Nature·Iain MathiesonDavid Reich
Apr 24, 2018·PloS One·Jose Manuel Monroy KuhnTorsten Günther
Nov 28, 2018·Nature Communications·Thiseas C LamnidisStephan Schiffels

❮ Previous
Next ❯

Citations

Jul 1, 2021·Cell Reports·Julian SusatBen Krause-Kyora

❮ Previous
Next ❯

Methods Mentioned

BETA
PCA
Human Genome Sequencing

Software Mentioned

BLASTN
custom
Admixtools
qpAdm
Schmutzi
mapDamage
lcMLkin
Adobe Illustrator Illustrator CS
ADMIXTURE
Smartpca

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.