PMID: 3745123Sep 1, 1986Paper

Gene for an immunoglobulin-binding protein from a group G streptococcus

Journal of Bacteriology
S R FahnestockD Filpula

Abstract

The gene (spg) for an immunoglobulin G (IgG)-binding protein from a Streptococcus clinical isolate of Lancefield group G was cloned and expressed in Escherichia coli. The complete nucleotide sequence of the gene and 5'-flanking sequences was determined. The DNA sequence includes an open reading frame which encodes a hypothetical protein of 448 amino acid residues (Mr = 47,595). The 5' end of this open reading frame encodes a sequence resembling a typical secretion signal sequence, and the remainder of the encoded protein has features reminiscent of staphylococcal protein A and of streptococcal M6 protein, including repeated sequences and a similar C-terminal structure. Aside from this C-terminal structure, the encoded protein has little direct amino acid sequence homology to either protein A or M6 protein. In E. coli, the cloned gene directs the synthesis of a protein which binds to immunoglobulins, including rabbit immunoglobulin, goat IgG, and human IgG3(lambda). Its binding properties are similar to those of the protein G described by Björck and Kronvall (L. Björck and G. Kronvall, J. Immunol. 133:969-974, 1984), a type III Fc receptor from a group G streptococcus.

References

Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G M WahlG R Stark
Nov 14, 1973·Nature: New Biology·I TinocoJ Bralla
Sep 15, 1973·Journal of Molecular Biology·F W Studier
Jun 1, 1981·Analytical Biochemistry·D S Holmes, M Quigley
May 25, 1983·Nucleic Acids Research·C J Duggleby, S A Jones
Jan 1, 1983·Methods in Enzymology·J Messing
Feb 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S LöfdahlM Lindberg
Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M D BigginG F Hong
Jan 16, 1984·European Journal of Biochemistry·B GussJ Sjödahl
Jun 1, 1983·European Journal of Biochemistry·G von Heijne
Jan 1, 1980·Methods in Enzymology·F L Adler, L T Adler
Jan 1, 1982·Analytical Biochemistry·R HawkesJ Gordon

❮ Previous
Next ❯

Citations

Oct 5, 1990·European Journal of Biochemistry·P A NygrenM Uhlén
Apr 1, 1988·Journal of Molecular Recognition : JMR·P A NygrenE Palmcrantz
Oct 15, 1987·European Journal of Biochemistry·A OlssonM Uhlén
Jan 26, 2008·Animal Health Research Reviews·Lynette B Corbeil
May 17, 2011·Biochemistry. Biokhimii︠a︡·E V Sidorin, T F Solov'eva
Dec 22, 1989·European Journal of Biochemistry·C LjungquistM Uhlén
Jul 1, 1988·European Journal of Biochemistry·G von Heijne, Y Gavel
Aug 1, 1988·FEBS Letters·J RühlmannF J Fehrenbach
Sep 1, 1994·Nature Structural Biology·F J BlancoL Serrano
Sep 1, 1995·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·K Sippel, C Lämmler
Oct 25, 1996·The Journal of Biological Chemistry·M de ChâteauL Björck
Sep 25, 1999·Oral Microbiology and Immunology·Z N YuanK Helgeland
Sep 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Yanan HeJohn Orban
Jul 4, 2012·Chemical Communications : Chem Comm·Taro IchimuraTomonobu M Watanabe
Feb 1, 1996·European Journal of Biochemistry·M WikströmT Drakenberg
Jan 1, 1991·Preparative Biochemistry·E L Faulmann, M D Boyle
Sep 1, 1993·FEMS Microbiology Reviews·G G Pritchard, T Coolbear
Jul 5, 2007·Proceedings of the National Academy of Sciences of the United States of America·Patrick A AlexanderPhilip N Bryan
Oct 4, 2012·FEMS Microbiology Reviews·Elizabeth Carmel Murphy, Inga-Maria Frick
Jul 23, 2014·Proceedings of the National Academy of Sciences of the United States of America·William B Monteith, Gary J Pielak
Aug 3, 2016·Journal of Molecular Recognition : JMR·Chunnian SongGuangju Chen
Mar 15, 1994·European Journal of Biochemistry·H Jonsson, H P Müller

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.