Gene-gene interaction between FGF20 and MAOB in Parkinson disease

Annals of Human Genetics
X GaoEden R Martin

Abstract

The fibroblast growth factor 20 (FGF20) and monoamine oxidase B (MAOB) genes are associated with Parkinson Disease (PD) risk and both are in the dopamine bio-pathway. Therefore, we investigated the joint effect between polymorphisms in the FGF20 and MAOB genes for evidence of interaction contributing to PD risk. Fourteen polymorphisms (eight for FGF20, six for MAOB) were genotyped in 736 families and analyzed using conditional logistic regression (CLR). Significant two-locus interactions were found in females between the polymorphisms rs1721100 of FGF20 and rs1799836 of MAOB, and between the polymorphisms rs1721082 of FGF20 and rs1799836 of MAOB. The risk alleles for each SNP identified from CLR, rs1721100 C, rs1721082 T and rs1799836 A, are consistent with previous reports. Using indicator variables for the SNP genotypes, rs1721100 GC with rs1799836 AA showed significant interaction (P = 0.021), compared with the reference group rs1721100 GG with rs1799836 GG. Using an allele-dose model for the risk alleles, rs1721100 and rs1799836 showed significant interaction (P = 0.019). We found similar interaction results between rs1721082 and rs1799836. In conclusion, variants in FGF20 and MAOB show evidence of statistical interactions,...Continue Reading

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Citations

Oct 14, 2010·Journal of Biochemistry·Nobuyuki Itoh, David M Ornitz
Feb 15, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Stephan KlebeUNKNOWN International Parkinson's Disease Genomics Consortium (IPDGC)
Aug 7, 2009·Journal of Neural Transmission·Andrea M DlugosHarriet de Wit
Jun 20, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ruixia ZhuZhiyi He
Jan 13, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Christian WiderOwen A Ross
Mar 31, 2009·American Journal of Human Genetics·Xiaoyi GaoWilliam K Scott
Jul 18, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ze-Gang MaTian-Wei Liu
Jan 28, 2015·Neurobiology of Aging·Ji-Feng GuoBei-Sha Tang
Aug 14, 2009·Expert Review of Neurotherapeutics·Makoto Naoi, Wakako Maruyama
Sep 21, 2019·Nature Communications·Gang FangChad L Myers

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