Gene imprinting in developmental toxicology: a possible interface between physiology and pathology

Toxicology Letters
J A McLachlanS F Li

Abstract

Gene imprinting is an epigenetic mechanism for accomplishing persistent change in gene expression. In this brief paper, we explore the mechanisms for imprinting genes and present data showing that the synthetic estrogen, diethylstilbestrol (DES) can developmentally imprint genes by changing the pattern of DNA methylation. We further discuss the implications of this and other findings for non-mutagenic aspects of developmental toxicology, and suggest ways to use this concept in modifying in vitro screening for developmental toxicants.

References

Jul 1, 1976·Cancer·R Hertz
May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·D M Ignar-TrowbridgeK S Korach
Jan 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·K G NelsonJ A McLachlan
Nov 1, 1990·Endocrine Reviews·J J Li, S A Li
Mar 1, 1986·Endocrinology·Y TomookaJ A McLachlan
Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·N YokomoriM Negishi
Jan 1, 1996·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·K KamiyaT Iguchi
Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·S W CurtisK S Korach
May 17, 2000·Proceedings of the National Academy of Sciences of the United States of America·A T FergusonS Sukumar
May 9, 2012·The Journal of Endocrinology·Melyssa R BrattonMatthew E Burow

❮ Previous
Next ❯

Citations

Jul 2, 2008·Breast Cancer Research and Treatment·Ahmet KorkmazRussel J Reiter
Jul 9, 2004·Toxicology and Applied Pharmacology·Kimberly P MillerJodi A Flaws
Feb 14, 2004·Medical Hypotheses·Root Gorelick
Jun 15, 2012·Nature Reviews. Cancer·Cheryl Lyn Walker, Shuk-mei Ho
Oct 2, 2013·Human Reproduction Update·Catherine E Aiken, Susan E Ozanne
Mar 18, 2004·Journal of the National Cancer Institute·Michael P WaalkesBhalchandra A Diwan
Aug 10, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Seiichiro Sakao, Koichiro Tatsumi
Mar 31, 2010·Molecular Endocrinology·Tiffany G BredfeldtCheryl L Walker
May 22, 2010·Environmental Health Perspectives·Paloma Alonso-MagdalenaAngel Nadal
Mar 24, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Catherine Gallou-KabaniClaudine Junien
Jan 11, 2011·Interdisciplinary Toxicology·Ahmet KorkmazTurgut Topal
Jun 1, 2008·Interdisciplinary Toxicology·Ahmet KorkmazRussel J Reiter
Oct 4, 2005·Brain & Development·Gyorgy Csaba, Kornélia Tekes
Dec 15, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Tapas ChakrabortyTaisen Iguchi
Dec 17, 2009·International Journal of Andrology·L Titus-ErnstoffR N Hoover
May 25, 2006·The Journal of Steroid Biochemistry and Molecular Biology·Wanjin TangMaria Norlin
Nov 1, 2005·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Alicia R Timme-LaragyRichard T Di Giulio
Feb 24, 2015·Journal of Developmental Origins of Health and Disease·E E HatchR N Hoover
May 14, 2005·American Journal of Obstetrics and Gynecology·Ellen K Silbergeld, Thelma E Patrick
Jul 12, 2008·Respiratory Medicine·Stefan KarraschRudolf A Jörres
Apr 5, 2014·Thérapie·Michel TournaireEmmanuel Devouche
Mar 30, 2002·Cadernos de saúde pública·Ellen K SilbergeldKen M Brown
Apr 23, 2008·Laboratory Investigation; a Journal of Technical Methods and Pathology·Adrienne S McCampbellPeter J A Davies
Jul 20, 2006·Cell Biochemistry and Function·G CsabaEva Pállinger
May 26, 2006·International Journal of Epidemiology·Linda Titus-ErnstoffRobert N Hoover
Jul 26, 2002·The Journal of Biological Chemistry·Jürgen ZschockeChristian Behl
May 11, 2002·The Proceedings of the Nutrition Society·Miriam N Jacobs, David F V Lewis
Nov 16, 2020·Differentiation; Research in Biological Diversity·Taisen IguchiNoboru Takasugi
Mar 27, 2009·Environmental Science & Technology·Anke LangeCharles R Tyler

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.