Gene loops function to maintain transcriptional memory through interaction with the nuclear pore complex.

Genes & Development
Sue Mei Tan-WongNick J Proudfoot

Abstract

Inducible genes in yeast retain a "memory" of recent transcriptional activity during periods of short-term repression, allowing them to be reactivated faster when reinduced. This confers a rapid and versatile gene expression response to the environment. We demonstrate that this memory mechanism is associated with gene loop interactions between the promoter and 3' end of the responsive genes HXK1 and GAL1FMP27. The maintenance of these memory gene loops (MGLs) during intervening periods of transcriptional repression is required for faster RNA polymerase II (Pol II) recruitment to the genes upon reinduction, thereby facilitating faster mRNA accumulation. Notably, a sua7-1 mutant or the endogenous INO1 gene that lacks this MGL does not display such faster reinduction. Furthermore, these MGLs interact with the nuclear pore complex through association with myosin-like protein 1 (Mlp1). An mlp1Delta strain does not maintain MGLs, and concomitantly loses transcriptional memory. We predict that gene loop conformations enhance gene expression by facilitating rapid transcriptional response to changing environmental conditions.

References

Jun 14, 2002·Cell·Kojiro IshiiUlrich K Laemmli
Aug 18, 2004·Nature Genetics·Justin M O'SullivanNick J Proudfoot
Sep 30, 2004·PLoS Biology·Jason H Brickner, Peter Walter
Feb 5, 2005·The EMBO Journal·Patrizia VinciguerraFrançoise Stutz
Dec 2, 2005·Genes & Development·Athar Ansari, Michael Hampsey
Feb 4, 2006·Molecular Cell·Manfred SchmidUlrich K Laemmli
Dec 13, 2006·The Journal of Biological Chemistry·Roopa LuthraAnita H Corbett
Apr 18, 2007·Genes & Development·Sharmistha KunduCraig L Peterson
Sep 7, 2007·Molecular Cell·Badri Nath Singh, Michael Hampsey
Nov 13, 2007·Current Biology : CB·Ioannis ZacharioudakisDimitris Tzamarias
Apr 1, 2008·Proceedings of the National Academy of Sciences of the United States of America·Sue Mei Tan-WongMelissa A Brown
Nov 26, 2009·Genes & Development·Jean-Philippe LainéMichael Hampsey

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Citations

Nov 19, 2011·Chromosoma·Chunhui Hou, Victor G Corces
Apr 16, 2013·Chromosoma·Jérôme O RouvièreBenoit Palancade
Jun 5, 2013·Chemical Reviews·C A NiñoC Dargemont
Mar 15, 2012·Nature Communications·Yong DingZoya Avramova
Jun 26, 2013·Nature Genetics·Tim R MercerJohn A Stamatoyannopoulos
Jul 23, 2013·Nature Immunology·Silvia Monticelli, Gioacchino Natoli
Mar 20, 2010·Nature Reviews. Genetics·Raphaël Margueron, Danny Reinberg
Jun 24, 2010·Nature Reviews. Molecular Cell Biology·Caterina Strambio-De-CastilliaMichael P Rout
Oct 24, 2012·Nature Reviews. Molecular Cell Biology·Marcela Raices, Maximiliano A D'Angelo
Mar 7, 2013·Nature Structural & Molecular Biology·Giacomo Cavalli, Tom Misteli
May 16, 2012·Proceedings of the National Academy of Sciences of the United States of America·Aboudi M MoabbiAthar Ansari
Nov 2, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jayasha ShandilyaStefan G E Roberts
Aug 19, 2011·The Journal of Biological Chemistry·Bo O Zhou, Jin-Qiu Zhou
Feb 11, 2012·Molecular Biology of the Cell·Erin M GreenKarsten Weis
Jan 27, 2012·Briefings in Functional Genomics·Sevil Sofueva, Suzana Hadjur
May 21, 2010·Cold Spring Harbor Perspectives in Biology·Carmelo FerraiAna Pombo
Apr 20, 2011·Cold Spring Harbor Symposia on Quantitative Biology·M CapelsonM W Hetzer
May 19, 2011·Development, Growth & Differentiation·Michelle StevenseTetsuya Muramoto
Sep 29, 2012·Science·Sue Mei Tan-WongNick J Proudfoot
Nov 3, 2012·Science·Michael Hampsey
May 16, 2012·Molecular and Cellular Biology·Joshua D LarkinArgyris Papantonis
Mar 10, 2010·Molecular and Cellular Biology·Sharmistha Kundu, Craig L Peterson
Jan 20, 2011·PLoS Biology·Jamie M KramerAnnette Schenck
Mar 8, 2013·PLoS Genetics·Yun LiangMartin W Hetzer
Dec 5, 2012·PloS One·Jennifer A MitchellPeter Fraser
Sep 12, 2012·Genetics·Angela Taddei, Susan M Gasser
Aug 2, 2012·Genetics·Qiaoning GuanAudrey P Gasch
Dec 24, 2013·Journal of Experimental Botany·Katarzyna Rataj, Gordon G Simpson
Oct 15, 2013·Molecular Biology and Evolution·Zhiming DaiXianhua Dai
Oct 25, 2013·Molecular Biology of the Cell·Mario NiepelCaterina Strambio-De-Castillia
May 15, 2012·Annual Review of Biophysics·Einat GrossmanMonika Zwerger
Nov 7, 2012·Biochimica Et Biophysica Acta·Giorgio DieciRoberto Ferrari
Jun 20, 2014·Molecular Biology of the Cell·Abigail L BuchwalterMartin W Hetzer
Oct 25, 2014·Nucleic Acids Research·Ralph S GrandJustin M O'Sullivan
Mar 12, 2013·The Journal of Biological Chemistry·Banupriya Mukundan, Athar Ansari
Mar 9, 2011·The Journal of Cell Biology·Christophe Zimmer, Emmanuelle Fabre
Sep 3, 2014·Journal of Molecular Biology·Danling ZhuCaroline Dean
Jul 30, 2014·Journal of Molecular Biology·Marina Lusic, Mauro Giacca
Jun 26, 2012·Methods : a Companion to Methods in Enzymology·Iris HövelMaike Stam
Jan 5, 2016·Nature Communications·Luciana BatistaFatima Mechta-Grigoriou
May 24, 2011·Trends in Genetics : TIG·Wu WeiLars M Steinmetz

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