Gene mutation detection of urinary sediment cells for NMIBC early diagnose and prediction of NMIBC relapse after surgery

Medicine
Feng ZhuDong-Kui Song

Abstract

Early diagnose of bladder cancer could lead to good prognosis and high 5-year-survival rate. Among bladder cancer, about 75% patients with were nonmuscle-invasive bladder cancer (NMIBC). Patients were painful and easily get infected during bladder cancer diagnosis, which mainly depends on invasive cystoscopy and low-sensitivity urine exfoliation cytology. Meanwhile, relapse after surgery was also becoming the major problem for patients. Exploring noninvasive, high-sensitivity, and painless method is very important and meaningful for NMIBC treatment.Firstly, we found potential related gene mutation sites for NMIBC by searching COSMIC database and related study. Urinary sediment cells of patients both in normal group (patients with benign) and NMIMC group were collected before and after operation for potential gene mutation site detecting. Meanwhile, the urinary sediment cells of relapse patients and good prognosis people in NMIBC group after surgery were also collected for further Gene mutation detection and NMIBC relapse after surgery prediction.Fourteen genes (152 mutation sites) were selected between 95 NMIBC patients and 67 control patients, which were FGFR3, TP53, PIK3CA, and others. Compared with control group, mutation ra...Continue Reading

References

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Citations

Dec 5, 2019·Expert Review of Molecular Diagnostics·Antonio Lopez-BeltranRodolfo Montironi
Feb 15, 2020·Investigative and Clinical Urology·Jayoung KimWun-Jae Kim
May 27, 2020·Current Opinion in Urology·Iris E ErtlYohann Loriot
Jun 17, 2020·BJU International·Anouk E HentschelJakko A Nieuwenhuijzen

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Methods Mentioned

BETA
biopsy
urine sediment
urine

Software Mentioned

SPSS

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