Gene \Narcotic Attenuation Program attenuates substance use disorder, a clinical subtype of reward deficiency syndrome

Advances in Therapy
Thomas J H ChenTomas Palomo


This study evaluated the effects of a putative activator of brain reward circuitry on outcomes in a 1-y prospective comprehensive outpatient clinical program. As part of the Gene Narcotic Attenuation Program, Haveos (Synaptamine)(TM) was administered for the treatment of substance use disorder. Seventy-six patients (45 males and 31 females; mean age, 33 y [standard deviation, 7.0]) who had been given a diagnosis of serious substance use disorder were recruited. After exclusion of 15 patients who dropped out before the end of the study, self-reported craving decreased from program entrance to 12 wk (visual analog scale whereby 0 represents no craving and 5, the strongest craving) for 61 compliant patients (mean decrease, 2.85, 95% confidence interval [CI], 2.65, 3.05); this improvement was significant (P<.001). Building up to relapse scores (each of 5 individual items and summary value) showed similar improvement after 1 y of treatment; the mean decrease in scores was significant for stress (t=3.3; P=.002), depression (t=4.0; P<.001), anger (t=4.4; P<.001), anxiety (t=4.5, P<.001), drug craving (t=5.4, P<.001), and summary building up to relapse (t=4.1; P<.001). Also, recovery score measures of energy level (t=8.4; P<.001) and a...Continue Reading


Apr 18, 1990·JAMA : the Journal of the American Medical Association·K BlumJ B Cohn
Apr 1, 1990·Journal of Psychoactive Drugs·R J BrownM C Trachtenberg
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G Di Chiara, A Imperato
Apr 1, 1997·Clinical EEG (electroencephalography)·J F DeFranceK Blum
Jun 8, 1999·Archives of General Psychiatry·D D SimpsonM D Anglin
Dec 6, 2000·Progress in Brain Research·D E Comings, K Blum
Jun 20, 2003·The European Journal of Neuroscience·Martin WermeStefan Brené
Dec 4, 2003·European Psychiatry : the Journal of the Association of European Psychiatrists·G PonceT Palomo
Oct 1, 2004·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Abdalla Bowirrat, Marlene Oscar-Berman
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Kyoung-Shim KimPyung-Lim Han
Aug 26, 2006·Alcoholism, Clinical and Experimental Research·Ann M Manzardo, Elizabeth C Penick


Jan 11, 2018·Journal of Behavioral Addictions·Thomas McLaughlinRajendra D Badgaiyan

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