Gene networks in development

Journal of Theoretical Biology
E R JacksonW G Nash

Abstract

A model is presented for the formation of temporal and spatial patterns of cell types during the development of organisms. It is demonstrated that very simple random networks of interactions among genes that affect expression may lead to the autonomous development of patterns of cell types. It is required that the networks contain active feedback loops and that there is limited communication among cells. The only elements of the model, gene interactions, are specified by the DNA nucleotide sequences of the genes. Therefore, the model readily explains how the control of development is specified by the organism's DNA. In the context of this model, the formation of positional information and its interpretation becomes a single process.

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Citations

Apr 12, 2013·Bulletin of Mathematical Biology·Matan BodakerEduardo Mitrani
Mar 17, 2011·IET Systems Biology·C DamianiA Colacci
Mar 26, 2002·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Hidde de Jong
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Mar 5, 2009·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Thimo Rohlf
Mar 24, 2021·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Hong LiYixue Li

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