Gene organization and chromosome location of the neural-specific RNA binding protein Elavl4

Gene
M V InmanG C Owens

Abstract

We have isolated the gene that encodes the neural-specific RNA binding protein HuD in the mouse (Elavl4), and have mapped its location to the mid-distal region of chromosome 4, close to the neurological mutant clasper. The coding region of the Elavl4 gene covers approximately 44 kb; the first two RNA binding domains (RBDs) that are homologous to the two RBDs found in the Drosophila sex-lethal gene are each encoded in two exons, whereas the third RBD is encoded in a single exon. Elavl4 mRNAs are alternatively spliced in the region between RBDs 2 and 3 due to the variable use of two micro-exons, and RNase protection analysis indicates that two of four possible splice variants are the predominant isoforms expressed in the central nervous system. The high degree of sequence conservation between the Hu proteins suggests that the exon organization of all the Hu protein genes will be similar, if not identical, to the Elavl4 gene.

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Citations

Sep 5, 1998·Brain Research. Developmental Brain Research·G H ClaytonG C Owens
Jun 12, 2003·Genome Research·Natalia VolfovskySteven L Salzberg
May 1, 2001·Biochemical and Biophysical Research Communications·F Nassar, M Wegnez
Aug 15, 2013·Research in Veterinary Science·Cristiano BombardiRoberto Chiocchetti
Aug 24, 2006·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Julie Deschênes-FurryBernard J Jasmin
Jan 18, 2014·Journal of Anatomy·C SorteniR Chiocchetti
Mar 25, 2014·Research in Veterinary Science·Augusta ZannoniNoemi Romagnoli
Mar 3, 2007·The EMBO Journal·Diana BellaviaIsabella Screpanti

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