Gene panel model predictive of outcome in men at high-risk of systemic progression and death from prostate cancer after radical retropubic prostatectomy.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
John C ChevilleGeorge Vasmatzis

Abstract

In men who are at high-risk of prostate cancer, progression and death from cancer after radical retropubic prostatectomy (RRP), limited prognostic information is provided by established prognostic features. The objective of this study was to develop a model predictive of outcome in this group of patients. Candidate genes were identified from microarray expression data from 102 laser capture microdissected prostate tissue samples. Candidates were overexpressed in tumor compared with normal prostate and more frequently in Gleason patterns 4 and 5 than in 3. A case control study of 157 high-risk patients, matched on Gleason score and stage with systemic progression or death of prostate cancer as the end point, was used to evaluate the expression of candidate genes and build a multivariate model. Tumor was collected from the highest Gleason score in paraffin-embedded blocks and the gene expression was quantified by real-time reverse transcription polymerase chain reaction. Validation of the final model was performed on a separate case-control study of 57 high-risk patients who underwent RRP. A model incorporating gene expression of topoisomerase-2a, cadherin-10, the fusion status based on ERG, ETV1, and ETV4 expression, and the ane...Continue Reading

References

Oct 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K J PientaL E Flaherty
Jun 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·I F TannockK C Murphy
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P W KantoffN J Vogelzang
Jul 11, 2000·Archives of Pathology & Laboratory Medicine·D G BostwickJ W Yarbro
Aug 17, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S LoricP Eschwège
Jun 28, 2002·Cancer Cell·Dinesh SinghWilliam R Sellers
Dec 7, 2002·Nature Genetics·Sridhar RamaswamyTodd R Golub
Dec 20, 2002·The New England Journal of Medicine·Marc J van de VijverRené Bernards
Feb 21, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Peter A Humphrey
Apr 7, 2004·The Journal of Clinical Investigation·Gennadi V GlinskyWilliam L Gerald
Apr 30, 2004·The New England Journal of Medicine·Izidore S LossosRonald Levy
Sep 11, 2004·Current Molecular Medicine·Arnab Roy Chowdhury, Hemanta K Majumder
Jun 9, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Mark A RubinJan-Erik Johansson
Jul 16, 2005·Scandinavian Journal of Urology and Nephrology. Supplementum·Jonathan I EpsteinRodolfo Montironi
Oct 29, 2005·Science·Scott A TomlinsArul M Chinnaiyan
Feb 24, 2006·Nature Reviews. Cancer·Michael L WhitfieldCharles M Perou
Mar 15, 2006·Neoplasia : an International Journal for Oncology Research·Tarek A BismarMark A Rubin
Sep 6, 2006·The Journal of Urology·Michael E RayRajal B Shah
Jan 17, 2007·Cancer Biology & Therapy·Marcella Macaluso, Antonio Giordano
Jan 30, 2007·Journal of Clinical Pathology·Ashish B RajputDavid G Huntsman
Mar 19, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Farhad KosariGeorge Vasmatzis

❮ Previous
Next ❯

Citations

Apr 18, 2009·Current Urology Reports·Michael C Risk, Daniel W Lin
Oct 1, 1990·FEMS Microbiology Letters·T HoraudG de Cespédès
Jun 1, 1995·Trends in Microbiology·D B ClewellD D Jaworski
Sep 8, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Roula AlbadineGeorge J Netto
Jul 12, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Antoun ToubajiGeorge J Netto
Jan 26, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Ritu BhallaNallasivam Palanisamy
Aug 20, 2010·Nature Reviews. Cancer·Donal J BrennanWilliam M Gallagher
Dec 24, 2008·Nature Reviews. Genetics·John S Witte
Jun 14, 2013·Omics : a Journal of Integrative Biology·Nadège RabiauDominique Bernard-Gallon
Nov 29, 2012·The Cancer Journal·Zhi Ven Fong, Jordan M Winter
Mar 18, 2010·BMC Medical Genomics·Andrea SbonerOve Andrén
May 4, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kathryn L PenneyLorelei A Mucci
Sep 2, 2010·PloS One·Regina Berretta, Pablo Moscato
Dec 19, 2013·PloS One·Christian R GomezStanimir Vuk-Pavlović
Nov 26, 2013·Biomarkers in Medicine·Sara Moscovita Falzarano, Cristina Magi-Galluzzi
Jan 8, 2014·Prostate Cancer and Prostatic Diseases·Z PengC Li
Jul 2, 2010·Annual Review of Genomics and Human Genetics·Prue A CowinDavid D L Bowtell
Nov 29, 2012·Journal of Cancer Research and Clinical Oncology·Naveen Kachroo, Vincent J Gnanapragasam
May 15, 2010·Human Pathology·Matei Andreoiu, Liang Cheng
May 5, 2009·European Urology·Scott A TomlinsJack A Schalken
Apr 29, 2015·European Urology·Peter J BoströmMatthew R Cooperberg
Jun 26, 2012·Journal of Surgical Oncology·Jordan M WinterJonathan R Brody
May 9, 2016·Critical Reviews in Oncology/hematology·Alessandro Morlacco, R Jeffrey Karnes
Jul 6, 2016·Frontiers in Oncology·Ingrid EspinozaChristian R Gomez
Apr 16, 2016·Asian Journal of Andrology·Jonathan Shoag, Christopher E Barbieri
Dec 31, 2016·International Journal of Molecular Sciences·Dong Gui HuRobyn Meech
Jan 18, 2018·Nature Communications·A GanguliR Bashir
Nov 15, 2011·British Journal of Cancer·S E T LarkinC Aukim-Hastie
Dec 18, 2009·Expert Review of Molecular Diagnostics·Karina Dalsgaard Sørensen, Torben Falck Ørntoft
Jul 16, 2010·Expert Review of Molecular Diagnostics·Daniel J LewinshteinPeter S Nelson
Jul 6, 2014·Expert Review of Molecular Diagnostics·Vincent J Gnanapragasam
Dec 15, 2016·Oncotarget·Justin KomisarofHartmut Land

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Rohit MehraRajal B Shah
Proceedings of the National Academy of Sciences of the United States of America
Jacques LapointeJonathan R Pollack
© 2022 Meta ULC. All rights reserved