Gene plasticity in colonic circular smooth muscle cells underlies motility dysfunction in a model of postinfective IBS.

American Journal of Physiology. Gastrointestinal and Liver Physiology
Barun K ChoudhurySushil K Sarna

Abstract

The cellular mechanisms of motility dysfunction in postinfectious irritable bowel syndrome (PI-IBS) are not known. We used a rat model of neonatal inflammation to test the hypothesis that gene plasticity in colonic circular smooth muscle cells underlies motility dysfunction in PI-IBS. Mild/moderate or severe inflammation was induced in neonatal and adult rats. Experiments were performed in tissues obtained at 7 days (short term) and 6-8 wk (long term) after the induction of inflammation. Severe inflammation in neonatal rats induced persistent long-term smooth muscle hyperreactivity to acetylcholine (ACh), whereas that in adult rat caused smooth muscle hyporeactivity that showed partial recovery in the long term. Mild/moderate inflammation had no effect in neonatal rats, but it induced smooth muscle hyporeactivity to ACh in adult rats, which recovered fully in the long term. Smooth muscle hyperreactivity to ACh resulted in accelerated colonic transit and increase in defecation rate, whereas hyporeactivity had opposite effects. Smooth muscle hyperreactivity to ACh was associated with increase in transcription rate of key cell-signaling proteins of the excitation-contraction coupling alpha1C subunit of Cav1.2 (L-type) calcium chan...Continue Reading

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Citations

Oct 1, 1991·Chaos·Gordon L. Telford, Sushil K. Sarna
Aug 8, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Xuan-Zheng Shi, Sushil K Sarna
Oct 16, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Xuan-Zheng ShiSushil K Sarna
Dec 15, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Xuan-Zheng Shi, Sushil K Sarna
Apr 21, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Qingjie Li, Sushil K Sarna
Nov 6, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Qingjie Li, Sushil K Sarna
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May 7, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·John H Winston, Sushil K Sarna
Sep 15, 2020·Frontiers in Psychiatry·Swapna Mahurkar-Joshi, Lin Chang

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