Gene polymorphisms of interleukin-10 and transforming growth factor beta in allergic rhinitis

Allergologia et immunopathologia
R NasiriNima Rezaei

Abstract

Allergic rhinitis (AR) is a polygenic inflammatory disorder of the upper respiratory airway with an increasing prevalence worldwide. Interleukin-10 (IL-10) and transforming growth factor-beta (TGF-β), as two cytokines with pleiotropic effects on both innate and adaptive immunity, play important roles in allergic responses. Therefore, this study was performed to evaluate the associations of five polymorphisms of IL-10 and TGF-β genes with AR. Ninety-eight patients with AR along with 140 healthy volunteers with no history of AR and with the same ethnicity of the patients were recruited in this study. Genotyping was done for three polymorphisms in promoter region of IL-10 gene (rs1800896, rs1800871, rs1800872), and two polymorphisms in the exonic region of TGF-β1 gene (rs1982037, rs1800471) using PCR sequence-specific-primers method. A allele and AA genotype in rs1800896 of IL-10 and TT genotype in rs1982037 in TGF-β were significantly less frequent in the patients than in controls. While the C allele and the CG genotype in rs1800471 in TGF-β1 were associated with a higher susceptibility to AR. C/C and T/C haplotypes (rs1982037, rs1800471) in TGF-β1 gene and A/C/A, A/T/C and G/C/A haplotypes (rs1800896, rs1800871, rs1800872) in IL...Continue Reading

References

Feb 1, 1997·Chest·J Grossman
Sep 14, 1999·The Journal of Allergy and Clinical Immunology·F E Simons
May 17, 2000·Proceedings of the National Academy of Sciences of the United States of America·M J MäkeläE W Gelfand
Jan 4, 2001·The New England Journal of Medicine·A B Kay
Mar 13, 2001·Annual Review of Immunology·K W MooreA O'Garra
Apr 9, 2001·Allergy·P H HowarthD Dokic
Jul 13, 2001·The Journal of Allergy and Clinical Immunology·D P Skoner
Apr 20, 2002·Cellular and Molecular Life Sciences : CMLS·L E N ReesP W Mathieson
Jul 10, 2003·Pulmonary Pharmacology & Therapeutics·Catherine DuvernelleNelly Frossard
Jan 30, 2004·Genetic Epidemiology·Helen LyonScott T Weiss
Jul 14, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D von BubnoffT Bieber
Oct 31, 2008·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Masoud MovahediAli Akbar Amirzargar
Nov 29, 2008·Cytokine & Growth Factor Reviews·Andrew J P Smith, Steve E Humphries
Dec 20, 2008·American Journal of Respiratory and Critical Care Medicine·Sunita SharmaJuan C Celedón
Feb 24, 2010·Inflammation·Elham BarkhordariNaser Ebrahimi-Daryani
Mar 16, 2012·European Journal of Human Genetics : EJHG·Lisbeth Venø KruseAnders Dupont Børglum
Jun 22, 2012·Genetic Testing and Molecular Biomarkers·Suman Latha GaddamVijayalakshmi Valluri
Oct 1, 2013·American Journal of Otolaryngology·Masoud MovahediNima Rezaei
Feb 26, 2014·Immunological Investigations·Shamsolmoulouk NajafiNima Rezaei
Jun 30, 2014·International Journal of Pediatric Otorhinolaryngology·Rasoul NasiriNima Rezaei

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Citations

Apr 10, 2021·Immunologic Research·Sara FalahiAli Gorgin Karaji

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