Gene promoter methylation is associated with increased mortality among women with breast cancer.

Breast Cancer Research and Treatment
Xinran XuJia Chen

Abstract

To better understand breast cancer etiology and progression, we explored the association between promoter methylation status of three breast cancer-related genes (BRCA1, APC, and p16) and survival in a large cohort of women with breast cancer. About 800 archived tumor tissues were collected from women diagnosed with a first primary invasive or in situ breast cancer in 1996-1997. The vital status of the participants was followed through the end of year 2005 with a mean follow-up time of 8.0 years. Promoter methylation was assessed by methylation-specific PCR (for BRCA1) and MethyLight (for APC and p16). The association of promoter methylation and breast cancer mortality was evaluated by Cox-proportional hazards models. Methylated promoters were found in 59.0, 48.4, and 3.6% of the tumor samples for BRCA1, APC, and p16, respectively. Breast cancer-specific mortality was strongly associated with promoter methylation of p16 [HR and 95% CI: 3.53 (1.83-6.78)], whereas the associations with of BRCA1 and APC were less pronounced [HR and 95% CI: 1.81 (1.18-2.78) and 1.46 (0.98-2.17), respectively]. Similar associations were observed with all-cause mortality. As the number of methylated genes increased, the risk of breast cancer-specific...Continue Reading

References

Mar 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R SilvestriniU Veronesi
Dec 1, 1994·American Journal of Epidemiology·J W Rich-EdwardsM J Stampfer
Jun 7, 1997·Biochimica Et Biophysica Acta·P Polakis
Feb 19, 1999·Journal of Epidemiology and Community Health·C Poole, K J Rothman
Mar 6, 1999·Breast Cancer Research and Treatment·C K Osborne
Apr 14, 1999·CA: a Cancer Journal for Clinicians·S H LandisP A Wingo
Nov 5, 1999·Seminars in Cancer Biology·J G Herman
Mar 21, 2000·The American Journal of Medicine·F Rosner
Apr 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·S Y LinM C Hung
Mar 10, 2001·Experimental Cell Research·J W Rocco, D Sidransky
Jul 12, 2001·Endocrine-related Cancer·X YangN E Davidson
Sep 20, 2001·Seminars in Cancer Biology·J L Hopper
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Aug 3, 2002·Oncogene·Martin Widschwendter, Peter A Jones
May 27, 2003·Journal of Cellular Physiology·Eliot M RosenItzhak D Goldberg
Aug 23, 2003·Biostatistics·M H GailR J Carroll
Jan 30, 2004·International Journal of Cancer. Journal International Du Cancer·Andreas WidschwendterMartin Widschwendter
May 6, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Fahd Al-MullaJehoram T Anim
Jul 19, 2006·Breast Cancer Research : BCR·Valgerdur BirgisdottirJorunn E Eyfjord
Aug 26, 2006·Breast Cancer Research and Treatment·Lisa M McShaneUNKNOWN Statistics Subcommittee of NCI-EORTC Working Group on Cancer Diagnostics
Nov 11, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Fabienne Patricia LiebensSerge Rozenberg
May 2, 2007·International Journal of Cancer. Journal International Du Cancer·Pal MollerC Michael Steel
Sep 15, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Rebecca J ClevelandMarilie D Gammon
Dec 19, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julie GralowUNKNOWN American Society of Clinical Oncology
Apr 10, 2008·Epigenetics : Official Journal of the DNA Methylation Society·George J KlarmannWilliam L Farrar
Jun 4, 2008·Breast Cancer Research and Treatment·Xinran XuJia Chen
Aug 19, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Xinran XuJia Chen
Nov 18, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Steven Van LaereLuc Dirix
May 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lorenzo RichiardiFranco Merletti

❮ Previous
Next ❯

Citations

Aug 13, 2011·Breast Cancer Research and Treatment·Yoon Hee ChoRegina M Santella
Apr 25, 2012·Breast Cancer Research and Treatment·Jing ShenRegina M Santella
Jul 6, 2013·Breast Cancer Research : BCR·Jia-Min B PangStephen B Fox
Sep 2, 2014·Journal of Cancer Therapeutics & Research·Priyanka SharmaRoy A Jensen
Aug 16, 2014·Biochemical and Biophysical Research Communications·Timothy M Barrow, Karin B Michels
Mar 8, 2016·Breast Cancer Research and Treatment·Lauren E McCulloughMarilie D Gammon
Nov 4, 2011·Epigenetics : Official Journal of the DNA Methylation Society·Xinran XuJia Chen
Dec 17, 2016·Cancer Biomarkers : Section a of Disease Markers·Saoussen Debouki-JoudiRaja Mokdad-Gargouri
May 20, 2009·Annals of Surgical Oncology·Frank A Orlando, Kevin D Brown
May 11, 2021·Journal, Genetic Engineering & Biotechnology·Amal RamadanMenha Swellam

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.

Breast Cancer: Chemo-Resistance

Some cancers are difficult to treat and aggressive including the "triple-negative" breast cancer. This type of cancer is chemoresistant even before chemotherapy begins. Here are the latest discoveries chemo-resistance in breast cancer.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Daniel P SilverJudy E Garber
Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Xinran XuJia Chen
© 2022 Meta ULC. All rights reserved