Gene promoter methylation signature predicts survival of head and neck squamous cell carcinoma patients

Epigenetics : Official Journal of the DNA Methylation Society
Efterpi KostareliJochen Hess

Abstract

Infection with high-risk types of human papilloma virus (HPV) is currently the best-established prognostic marker for head and neck squamous cell carcinoma (HNSCC), one of the most common and lethal human malignancies worldwide. Clinical trials have been launched to address the concept of treatment de-escalation for HPV-positive HNSCC with the final aim to reduce treatment related toxicity and debilitating long-term impacts on the quality of life. However, HPV-related tumors are mainly restricted to oropharyngeal SCC (OPSCC) and there is an urgent need to establish reliable biomarkers for all patients at high risk for treatment failure. A patient cohort (n = 295) with mainly non-OPSCC (72.9%) and a low prevalence of HPV16-related tumors (8.8%) was analyzed by MassARRAY to determine a previously established prognostic methylation score (MS). Kaplan-Meier revealed a highly significant correlation between a high MS and a favorable survival for OPSCC (P = 0.0004) and for non-OPSCC (P<0.0001), which was confirmed for all HNSCC by multivariate Cox regression models (HR: 9.67, 95% CI [4.61-20.30], P<0.0001). Next, we established a minimal methylation signature score (MMSS), which consists of ten most informative of the originally 62 C...Continue Reading

References

Feb 28, 1997·Statistics in Medicine·R Tibshirani
Sep 4, 1999·Statistics in Medicine·E GrafM Schumacher
Dec 3, 2003·The New England Journal of Medicine·Arlene A ForastiereJay Cooper
Dec 29, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susan UrbaJeremy Taylor
Jun 8, 2007·Bioinformatics·H M BøvelstadO C Lingjaerde
Apr 4, 2008·Statistical Applications in Genetics and Molecular Biology·Harald Binder, Martin Schumacher
Jan 30, 2009·Journal of the National Cancer Institute·J L LefebvreUNKNOWN EORTC Radiation Oncology Group
Mar 26, 2009·Journal of the National Cancer Institute·Yoann PointreauGilles Calais
Jun 10, 2010·The New England Journal of Medicine·K Kian AngMaura L Gillison
Dec 17, 2010·Nature Reviews. Cancer·C René LeemansRuud H Brakenhoff
Oct 5, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anil K ChaturvediMaura L Gillison
Jun 1, 2012·Epigenetics : Official Journal of the DNA Methylation Society·Rainer ClausChristoph Plass
Jan 5, 2013·British Journal of Cancer·P V JitheshR J Shaw
Jan 9, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Brian O'SullivanWei Xu
Jan 24, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jean Louis LefebvreEtienne Bardet
May 3, 2013·The Journal of Clinical Investigation·Efterpi KostareliJochen Hess
Jun 27, 2013·Cancer Research·Laura A E HughesManon van Engeland
Sep 14, 2013·Blood·Elli PapaemmanuilUNKNOWN Chronic Myeloid Disorders Working Group of the International Cancer Genome Consortium
Oct 10, 2013·Nature Reviews. Genetics·Christoph PlassPeter Lichter
Oct 31, 2013·Epigenetics : Official Journal of the DNA Methylation Society·Pauline M W van KempenWilko Grolman
Dec 18, 2013·Oral Oncology·Jean-Damien Combes, Silvia Franceschi
Mar 14, 2014·International Journal of Cancer. Journal International Du Cancer·H MirghaniJ Lacau St Guily
Mar 25, 2014·Oral Oncology·L M R B ArantesE M Goloni-Bertollo
Jun 25, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carole FakhryMaura Gillison
Jul 13, 2014·Biochemical and Biophysical Research Communications·Hiromu SuzukiMasahiro Kai
Jul 25, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A PsyrriJ B Vermorken
Aug 6, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Liam MastersonPeter K C Goon
Nov 19, 2014·Nature Reviews. Clinical Oncology·Hyunseok KangChristine H Chung
Dec 30, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Pernille LassenUNKNOWN Danish Head and Neck Cancer Group (DAHANCA)
Jan 30, 2015·Nature·UNKNOWN Cancer Genome Atlas Network
Sep 10, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Assuntina G Sacco, Ezra E Cohen
Sep 10, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Aarti Bhatia, Barbara Burtness
Sep 10, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Magnus T Dillon, Kevin J Harrington
Sep 10, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D Neil HayesTanguy Y Seiwert

❮ Previous
Next ❯

Citations

Nov 3, 2016·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Maria CostalesMario A Hermsen
Jul 1, 2020·Experimental Biology and Medicine·HongLei WangHongTao Wang
Sep 16, 2020·International Journal of Cancer. Journal International Du Cancer·Michaela PlathKarim Zaoui
Nov 21, 2020·HNO·S LabanT K Hoffmann
Jul 1, 2020·Combinatorial Chemistry & High Throughput Screening·Yaojian JinMingxing Ding
Jul 31, 2020·Combinatorial Chemistry & High Throughput Screening·Nan LiDingyuan Zeng

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
genotyping

Software Mentioned

Bioconductor
R
Bioconductor library gplots
Rnw
MassARRAY
maxstat
LASSO
glmnet
pec

Related Concepts

Related Feeds

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Christine H ChungQuynh-Thu Le
Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Anthony C NicholsJames W Rocco
International Journal of Cancer. Journal International Du Cancer
H MirghaniJ Lacau St Guily
© 2022 Meta ULC. All rights reserved