PMID: 9524064Apr 2, 1998Paper

Gene regulation and extracellular functions of procathepsin L

Biological Chemistry
K Ishidoh, E Kominami

Abstract

Cathepsin L, a lysosomal cysteine proteinase, belongs to the papain family. This proteinase is different from the other members of the mammalian papain family cysteine proteinase in the following ways: (i) The cathepsin L gene is activated by a variety of growth factors and activated oncogenes. (ii) Procathepsin L, a precursor form of cathepsin L is secreted from various cells. (iii) The mRNA level of cathepsin L is related to the in vivo metastatic potential of the transformed cells. Thus, the regulation of the cathepsin L gene and the extracellular functions of secreted procathepsin L are tightly coupled. In this review, we describe these two points, which have recently been addressed in our laboratory.

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Citations

Feb 5, 2002·Annual Review of Physiology·JoAnne S RichardsLawrence L Espey
Aug 22, 2006·Cancer Biotherapy & Radiopharmaceuticals·Yoko HashimotoNobuhiko Katunuma
Sep 16, 2006·Biological Chemistry·Brigitte GouletAlain Nepveu
Nov 20, 2002·Biological Chemistry·Aline WilleFrank Bühling
Feb 15, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·A GerberF Bühling

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