PMID: 11310795Apr 20, 2001Paper

Gene regulation in melanoma progression by the AP-2 transcription factor

Pigment Cell Research
Menashe Bar-Eli

Abstract

The molecular changes associated with the transition of melanoma cells from radial growth phase (RGP) to vertical growth phase [(VGP), metastatic phenotype] are not very well defined. We previously demonstrated that expression of the cell-surface adhesion molecule MCAM/MUC18 correlates directly with the metastatic potential of human melanoma cells. In addition, the progression of human melanoma towards the metastatic phenotype is associated with loss of expression of the tyrosine-kinase receptor c-KIT. In this review, I will summarize our recent studies demonstrating that the expression of both genes is regulated by the AP-2 transcription factor. Moreover, we have observed a loss of AP-2 expression in metastatic melanoma cells. Re-expression of AP-2 in the highly metastatic A375SM cells decreased their tumorigenicity and inhibited their metastatic potential in nude mice. MCAM/MUC18 mRNA and protein expression was significantly down-regulated while c-KIT expression was up-regulated in the AP-2-transfected cells. To further investigate the role of AP-2 in the progression of human melanoma, we attempted to inactivate AP-2 in primary cutaneous melanoma by using a dominant-negative AP-2, or the AP-2B gene. Expression of AP-2B in SB-...Continue Reading

Citations

Aug 24, 2004·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Yarí E Marín, Suzie Chen
Nov 5, 2004·Naunyn-Schmiedeberg's Archives of Pharmacology·Christiane Kunert-KeilHeyo K Kroemer
Mar 24, 2005·Cancer Metastasis Reviews·Vanessa C Gray-SchopferRichard Marais
Jan 20, 2010·Clinical & Experimental Metastasis·Antonietta SiliniRaffaella Giavazzi
Feb 7, 2012·Carcinogenesis·Jens WulfängerBarbara Seliger
Jun 10, 2011·Pancreas·Catherine CarrièreMurray Korc
Oct 7, 2011·Pigment Cell & Melanoma Research·Jelena KrochmannChristian Busch
Sep 2, 2010·PloS One·Vladislava O MelnikovaMenashe Bar-Eli
Jul 27, 2006·Neoplasia : an International Journal for Oncology Research·Hualei LiFrederick E Domann
Jul 4, 2003·The Journal of Investigative Dermatology·Andrey A PanteleyevAngela M Christiano
Dec 17, 2014·The Journal of Investigative Dermatology·Elisa PennaDaniela Taverna
Jul 27, 2007·Experimental and Molecular Pathology·Matthew J ProvenzanoFrederick E Domann
Oct 1, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·J Zhang, T Williams
Jul 16, 2003·Pigment Cell Research·Sophia JuléJean-Jacques Panthier
Mar 29, 2003·Veterinary Dermatology·Shola S Sulaimon, Barbara E Kitchell
Sep 26, 2003·Journal of Cutaneous Pathology·Steven S ShenVictor G Prieto
Dec 9, 2003·Journal of Veterinary Internal Medicine·Shola S Sulaimon, Barbara E Kitchell
Mar 3, 2007·International Journal of Cancer. Journal International Du Cancer·Johanna M Pellikainen, Veli-Matti Kosma
Dec 31, 2008·Journal of Cellular Biochemistry·Xiaofeng DingJian Zhang
Jun 22, 2010·Journal of Cellular Biochemistry·Uk Yeol MoonJoo-Heon Yoon
Dec 18, 2007·Seminars in Oncology·Meenhard HerlynDaniel Pinkel
May 11, 2013·The International Journal of Biochemistry & Cell Biology·Xiaofeng DingJian Zhang
Feb 21, 2004·Developmental Biology·Stephanie BrewerTrevor Williams
May 2, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hao WangYong Zhao
Nov 17, 2005·Oncogene·P R StabachR J Weigel
Jun 3, 2004·International Journal of Surgical Pathology·Dimitrios StefanouNiki J Agnantis

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