PMID: 9555535Apr 29, 1998Paper

Gene replacement strategies for lung cancer

Current Opinion in Oncology
Jack A Roth

Abstract

Considerable evidence has accumulated that cancer has a genetic origin based on the development of somatic mutations in families of genes responsible for critical functions of cellular DNA repair, growth control, and division. Restoration of the function of a single pivotal gene product appears sufficient to mediate antitumor effects that are potentially clinically significant. For example, restoration of wild-type p53 function in the cancer cell by gene transfer is sufficient to cause either cell-cycle arrest or apoptosis. This effect is not restricted to p53 but has been observed for oncogenes and other tumor suppressor genes as well. Genes can be delivered with sufficient efficiency by direct intratumoral injection to mediate tumor regression as shown in preclinical studies and phase I clinical trials in non-small cell lung cancer. Although clinical trials of gene replacement are in the earliest stages, this treatment offers a unique mechanism of action with a potentially high therapeutic index.

Citations

Nov 27, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·U LiebersC Witt
Jul 18, 2000·Anti-cancer Drugs·W DempkeH J Schmoll
Jan 24, 2007·Thoracic Surgery Clinics·Eric M Toloza
Oct 29, 2005·Seminars in Thoracic and Cardiovascular Surgery·Eric M Toloza
Mar 21, 2002·Clinics in Chest Medicine·Steven M AlbeldaDaniel H Sterman
Jun 13, 2006·Journal of Cellular Biochemistry·Eric M TolozaH Kim Lyerly
Apr 15, 2000·Annals of Internal Medicine·S M AlbeldaJ B Zuckerman

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