Gene Signature of Human Oral Mucosa Fibroblasts: Comparison with Dermal Fibroblasts and Induced Pluripotent Stem Cells

BioMed Research International
Keiko MiyoshiTakafumi Noma

Abstract

Oral mucosa is a useful material for regeneration therapy with the advantages of its accessibility and versatility regardless of age and gender. However, little is known about the molecular characteristics of oral mucosa. Here we report the first comparative profiles of the gene signatures of human oral mucosa fibroblasts (hOFs), human dermal fibroblasts (hDFs), and hOF-derived induced pluripotent stem cells (hOF-iPSCs), linking these with biological roles by functional annotation and pathway analyses. As a common feature of fibroblasts, both hOFs and hDFs expressed glycolipid metabolism-related genes at higher levels compared with hOF-iPSCs. Distinct characteristics of hOFs compared with hDFs included a high expression of glycoprotein genes, involved in signaling, extracellular matrix, membrane, and receptor proteins, besides a low expression of HOX genes, the hDFs-markers. The results of the pathway analyses indicated that tissue-reconstructive, proliferative, and signaling pathways are active, whereas senescence-related genes in p53 pathway are inactive in hOFs. Furthermore, more than half of hOF-specific genes were similarly expressed to those of hOF-iPSC genes and might be controlled by WNT signaling. Our findings demonstr...Continue Reading

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Citations

May 4, 2021·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Billur SezginKaan Ersoy
Jun 18, 2021·The FEBS Journal·Donovan Correa-Gallegos, Yuval Rinkevich
Aug 12, 2021·Npj Regenerative Medicine·Rita N GomesDiana S Nascimento

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Datasets Mentioned

BETA
GSE56805

Software Mentioned

DAVID
Exon RMA
GeneSpring

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